Clinical and genetic features of UNC13D deficiency with hypogammaglobulinemia

Clinical and genetic features of UNC13D deficiency with hypogammaglobulinemia

BackgroundUNC13D deficiency is the most common form of familial hemophagocytic lymphohistiocytosis (FHL) in Asia. Hypogammaglobulinemia is a rare phenotype observed in both patients with FHL3 and sporadic hemophagocytic lymphohistiocytosis (HLH). Our observations suggest that UNC13D deficiency with...

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Bibliographic Details
Main Authors:	Linyan Xiong, Qin Zhao, Qian Zhao, Zhiyong Zhang, Yunfei An, Xuemei Tang, Hirokazu Kanegane, Xi Yang, Xiaodong Zhao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Immunology
Subjects:	hemophagocytic lymphohistiocytosis familial hemophagocytic lymphohistiocytosis UNC13D hypogammaglobulinemia antibody deficiency
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1628507/full
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