Water-soluble cellulose acetate attenuates glucose intolerance through GLP-1 and PYY signal upregulation
Abstract Water-soluble cellulose acetate (WSCA), derived from natural cellulose and acetate, can be used as a food additive and deliver acetate to the large intestine. In this study, we investigated the effects of dietary WSCA supplementation on impaired glucose metabolism in db/db mice, a model of...
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Nature Portfolio
2025-07-01
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| Series: | npj Science of Food |
| Online Access: | https://doi.org/10.1038/s41538-025-00505-9 |
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| author | Kohei Asaeda Tomohisa Takagi Eiki Murakami Hikaru Hashimoto Takeshi Yasuda Mariko KajiwaraーKubota Takeshi Sugaya Katsura Mizushima Yasuki Higashimura Ohue-Kitano Ryuji Ikuo Kimura Ken Inoue Kazuhiko Uchiyama Shu Shimamoto Yuichi Ukawa Akiko Kohara Masatake Kudoh Yuji Naito Yoshito Itoh |
| author_facet | Kohei Asaeda Tomohisa Takagi Eiki Murakami Hikaru Hashimoto Takeshi Yasuda Mariko KajiwaraーKubota Takeshi Sugaya Katsura Mizushima Yasuki Higashimura Ohue-Kitano Ryuji Ikuo Kimura Ken Inoue Kazuhiko Uchiyama Shu Shimamoto Yuichi Ukawa Akiko Kohara Masatake Kudoh Yuji Naito Yoshito Itoh |
| author_sort | Kohei Asaeda |
| collection | DOAJ |
| description | Abstract Water-soluble cellulose acetate (WSCA), derived from natural cellulose and acetate, can be used as a food additive and deliver acetate to the large intestine. In this study, we investigated the effects of dietary WSCA supplementation on impaired glucose metabolism in db/db mice, a model of type 2 diabetes mellitus. db/m and db/db mice were fed either a control diet or a WSCA-supplemented diet for eight weeks. The WSCA-supplemented group exhibited improved glucose intolerance or lipid metabolism without any loss of skeletal muscle mass or grip strength. WSCA supplementation significantly increased acetate concentrations in the cecum, stool, and blood. Furthermore, serum levels of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) were significantly higher in the WSCA group than in the control group. These findings suggest that WSCA delivers acetate to the colon and prevents diabetes by enhancing GLP-1 and PYY secretion in db/db mice. |
| format | Article |
| id | doaj-art-798121b65bfe48c5a72b561d8a2caee6 |
| institution | Kabale University |
| issn | 2396-8370 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Science of Food |
| spelling | doaj-art-798121b65bfe48c5a72b561d8a2caee62025-08-20T03:45:38ZengNature Portfolionpj Science of Food2396-83702025-07-01911810.1038/s41538-025-00505-9Water-soluble cellulose acetate attenuates glucose intolerance through GLP-1 and PYY signal upregulationKohei Asaeda0Tomohisa Takagi1Eiki Murakami2Hikaru Hashimoto3Takeshi Yasuda4Mariko KajiwaraーKubota5Takeshi Sugaya6Katsura Mizushima7Yasuki Higashimura8Ohue-Kitano Ryuji9Ikuo Kimura10Ken Inoue11Kazuhiko Uchiyama12Shu Shimamoto13Yuichi Ukawa14Akiko Kohara15Masatake Kudoh16Yuji Naito17Yoshito Itoh18Department of Gastroenterology, Kyoto Yamashiro General Medical CenterDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical ScienceDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical ScienceDepartment of Gastroenterology, Osaka General Hospital of West Japan Railway CompanyDepartment of Gastroenterology, Akashi City HospitalDepartment of Gastroenterology, Fukuchiyama City HospitalDepartment of Gastroenterology, Dokkyo Medical UniversityDepartment of Human Immunology and Nutrition Science, Kyoto Prefectural University of MedicineDepartment of Food Science, Ishikawa Prefectural UniversityDepartment of Biological and Environmental Chemistry, Kindai UniversityLaboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto UniversityDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical ScienceDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical ScienceDaicel Corporation, R&D HeadquartersDaicel Corporation, R&D HeadquartersDaicel Corporation, Healthcare SBUDaicel Corporation, Healthcare SBUDepartment of Human Immunology and Nutrition Science, Kyoto Prefectural University of MedicineDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical ScienceAbstract Water-soluble cellulose acetate (WSCA), derived from natural cellulose and acetate, can be used as a food additive and deliver acetate to the large intestine. In this study, we investigated the effects of dietary WSCA supplementation on impaired glucose metabolism in db/db mice, a model of type 2 diabetes mellitus. db/m and db/db mice were fed either a control diet or a WSCA-supplemented diet for eight weeks. The WSCA-supplemented group exhibited improved glucose intolerance or lipid metabolism without any loss of skeletal muscle mass or grip strength. WSCA supplementation significantly increased acetate concentrations in the cecum, stool, and blood. Furthermore, serum levels of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) were significantly higher in the WSCA group than in the control group. These findings suggest that WSCA delivers acetate to the colon and prevents diabetes by enhancing GLP-1 and PYY secretion in db/db mice.https://doi.org/10.1038/s41538-025-00505-9 |
| spellingShingle | Kohei Asaeda Tomohisa Takagi Eiki Murakami Hikaru Hashimoto Takeshi Yasuda Mariko KajiwaraーKubota Takeshi Sugaya Katsura Mizushima Yasuki Higashimura Ohue-Kitano Ryuji Ikuo Kimura Ken Inoue Kazuhiko Uchiyama Shu Shimamoto Yuichi Ukawa Akiko Kohara Masatake Kudoh Yuji Naito Yoshito Itoh Water-soluble cellulose acetate attenuates glucose intolerance through GLP-1 and PYY signal upregulation npj Science of Food |
| title | Water-soluble cellulose acetate attenuates glucose intolerance through GLP-1 and PYY signal upregulation |
| title_full | Water-soluble cellulose acetate attenuates glucose intolerance through GLP-1 and PYY signal upregulation |
| title_fullStr | Water-soluble cellulose acetate attenuates glucose intolerance through GLP-1 and PYY signal upregulation |
| title_full_unstemmed | Water-soluble cellulose acetate attenuates glucose intolerance through GLP-1 and PYY signal upregulation |
| title_short | Water-soluble cellulose acetate attenuates glucose intolerance through GLP-1 and PYY signal upregulation |
| title_sort | water soluble cellulose acetate attenuates glucose intolerance through glp 1 and pyy signal upregulation |
| url | https://doi.org/10.1038/s41538-025-00505-9 |
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