Manual and automated synthesis of modified oligonucleotides on core–shell solid supports
A critical step in the manufacturing of oligonucleotides is the selection of ideal solid supports. Herein, we evaluate a hybrid core–shell solid support made of polystyrene and polyethyleneglycol, for the preparation of oligonucleotides using phosphoramidite chemistry. The results were compared with...
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| Main Authors: | Luis M. Menéndez-Méndez, Carme Fàbrega, Anna Aviñó, Ramon Eritja, Yoon-Sik Lee, Yogesh S. Sanghvi, Susana Fernández, Miguel Ferrero |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221171562400626X |
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