Manual and automated synthesis of modified oligonucleotides on core–shell solid supports

A critical step in the manufacturing of oligonucleotides is the selection of ideal solid supports. Herein, we evaluate a hybrid core–shell solid support made of polystyrene and polyethyleneglycol, for the preparation of oligonucleotides using phosphoramidite chemistry. The results were compared with...

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Bibliographic Details
Main Authors: Luis M. Menéndez-Méndez, Carme Fàbrega, Anna Aviñó, Ramon Eritja, Yoon-Sik Lee, Yogesh S. Sanghvi, Susana Fernández, Miguel Ferrero
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Results in Chemistry
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Online Access:http://www.sciencedirect.com/science/article/pii/S221171562400626X
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