Psilocin, the Psychoactive Metabolite of Psilocybin, Modulates Select Neuroimmune Functions of Microglial Cells in a 5-HT<sub>2</sub> Receptor-Dependent Manner

Psilocin, the Psychoactive Metabolite of Psilocybin, Modulates Select Neuroimmune Functions of Microglial Cells in a 5-HT<sub>2</sub> Receptor-Dependent Manner

Neuroinflammation that is caused by microglia, the main immune cells of the brain, contributes to neurodegenerative diseases. Psychedelics, including psilocybin and lysergic acid diethylamide (LSD), possess certain anti-inflammatory properties and, therefore, should be considered as drug candidates...

Full description

Saved in:

Bibliographic Details
Main Authors:	Kennedy R. Wiens, Noah A. H. Brooks, Ishvin Riar, Bridget K. Greuel, Ivan A. Lindhout, Andis Klegeris
Format:	Article
Language:	English
Published:	MDPI AG 2024-10-01
Series:	Molecules
Subjects:	affective disorders depression 5-hydroxytryptamine neurodegenerative diseases neuroprotection phagocytic activity
Online Access:	https://www.mdpi.com/1420-3049/29/21/5084
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Inhaling arsenic aggravates airway hyperreactivity by upregulating PNEC-sourced 5-HT in OVA-induced allergic asthma
by: Xue Lu, et al.
Published: (2025-01-01)

THE EFFECT OF BACTERIAL BIOINSECTICIDE ON THE MORPHOFUNCTIONAL STATUS OF HEMOCYTES BLAPTICA DUBIA
by: Elena A. Grebtsova, et al.
Published: (2024-08-01)

Bacteria--phagocyte dynamics,axiomatic modelling and mass-action kinetics
by: Roy Malka, et al.
Published: (2011-03-01)

Effects of sennoside A on atherosclerotic plaque formation and expression of 5-hydroxytryptamine signal moleculars in mice with diabetes mellitus type 2
by: LIU Meizhi, et al.
Published: (2024-08-01)

Extracellular Cardiolipin Modulates Select Immune Functions of Astrocytes in Toll-Like Receptor (TLR) 4-Dependent Manner
by: Taryn E. Murray, et al.
Published: (2022-01-01)

Effect and Mechanism of Catalpol on Behavior in Rats with Post-stroke Depression
by: WANG Xiangyu, et al.
Published: (2022-02-01)

Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety via Akkermansia muciniphila
by: Miaomiao Pan, et al.
Published: (2025-12-01)

Differential Modulation of Annexin I Binding Sites on Monocytes and Neutrophils
by: H. S. Euzger, et al.
Published: (1999-01-01)

PEG-Polymeric Nanocarriers Alleviate the Immunosuppressive Effects of Free 4-Thiazolidinone-Based Chemotherapeutics on T Lymphocyte Function and Cytokine Production
by: Tulinska J, et al.
Published: (2024-12-01)

Vitamin E nanoparticles enhance performance and immune status of Nile tilapia
by: Enas A. H. Farag, et al.
Published: (2024-12-01)

Structural Characteristics and Immunological Function of a New Non-Starch Polysaccharide from <i>Red Sprout</i> Taro
by: Sha Luo, et al.
Published: (2024-11-01)

5-HT7R enhances neuroimmune resilience and alleviates meningitis by promoting CCR5 ubiquitination
by: Zhenfang Gao, et al.
Published: (2025-02-01)

An integrated “Engage & Evasion” approach for mononuclear phagocyte system escape and efficient extracellular vesicle therapy
by: Hongman Liu, et al.
Published: (2024-12-01)

Development and Optimization of Indian Propolis Formulation for Enhanced Immunomodulatory Potential
by: Harshad S. Kapare, et al.
Published: (2024-10-01)

INFLUENCE OF VACUUM THERAPY ON THE DYNAMICS OF CELLULAR REACTIONS IN MODELING PURULENT INFLAMMATORY PROCESS IN RATS
by: Igor Zh. Seminsky, et al.
Published: (2024-12-01)

The immunity-promoting activity of porcine placenta in mice as an immunomodulator for functional foods
by: Zhiwei Zhou, et al.
Published: (2022-11-01)

Branched-Chain Amino Acid (BCAA) Oligopeptide Determination from Whey Proteins: Preparation, Peptide Profiles, and Anti-Fatigue Activity
by: Qiong Zhu, et al.
Published: (2024-12-01)

The influence of non-alcoholic fatty liver disease on the state of the macrophagal phagocytosis system in patients with community-acquired pneumonia.
by: R. V. Razumnyi
Published: (2018-04-01)

Assessment of the Combined Effects of Heavy Metal Cobalt and Sublethal Radiation on the Immune System
by: Gulzhan Ilderbayeva, et al.
Published: (2024-12-01)

Proton pump inhibitor effect on macrophage and neutrophil function: a systematic review
by: Josef F. Fowler, et al.
Published: (2024-12-01)

EFFECT OF DIETARY SUPPLEMENTATION OF VITAMIN E AND SELENIUM ON TOTAL ANTIOXIDANT STATUS AND IN VITRO IMMUNE COMPETENCE IN GROWER GHUNGROO PIGS
by: Rubayat Hussain, et al.
Published: (2024-12-01)

SARS-CoV-2 infection induces human milk antibodies capable of mediating multiple functional activities
by: Jared Sheehan, et al.
Published: (2024-12-01)

PM<sub>2.5</sub> Exposure Induces Glomerular Hyperfiltration in Mice in a Gender-Dependent Manner
by: Hao Wang, et al.
Published: (2024-12-01)

Impact of dietary-nucleotides and Saccharomyces cerevisiae-derivatives on growth-performance, antioxidant-capacity, immune-response, small-intestine histomorphometry, caecal-Clostridia, and litter-hygiene of broiler-chickens treated with florfenicol
by: Tamer Mohamed Abo-Sriea, et al.
Published: (2024-12-01)

Pro-neuroinflammatory and neurotoxic potential of extracellular histones H1 and H3
by: Seamus A. McRae, et al.
Published: (2024-07-01)

Diversity of Microglia-Derived Molecules with Neurotrophic Properties That Support Neurons in the Central Nervous System and Other Tissues
by: Kennedy R. Wiens, et al.
Published: (2024-11-01)

Fusobacterium nucleatum-driven CX3CR1+ PD-L1+ phagocytes route to tumor tissues and reshape tumor microenvironment
by: Fangfang Chen, et al.
Published: (2025-12-01)

Optimized psilocybin production in tryptophan catabolism‐repressed fungi
by: Slavica Janevska, et al.
Published: (2024-11-01)

Central amygdala neuroimmune signaling in alcohol use disorder
by: Mariam Melkumyan, et al.
Published: (2025-03-01)

5-HT<sub>2C</sub> Receptors in the BNST Modulate Contextual Fear Conditioning Without Affecting Acute Early Life Stress-Enhanced Fear Learning in Adult Rats
by: Brianna L. Minshall, et al.
Published: (2024-12-01)

Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners
by: Katarzyna Popiolek-Barczyk, et al.
Published: (2017-01-01)

Refractory CRPS pain treated with psilocybin: A case report
by: David S. Jevotovsky, et al.
Published: (2024-09-01)

Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review
by: Yue Lang, et al.
Published: (2018-01-01)

Neuroscience in peripheral cancers: tumors hijacking nerves and neuroimmune crosstalk
by: Hua‐Yang Fan, et al.
Published: (2024-11-01)

The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation
by: Ekta Bajwa, et al.
Published: (2019-01-01)

Mushrooms, Microdosing, and Mental Illness: The Effect of Psilocybin on Neurotransmitters, Neuroinflammation, and Neuroplasticity
by: Kinderlehrer DA
Published: (2025-01-01)

The (C<sub>2</sub>N<sub>2</sub>H<sub>10</sub>)[Cu(H<sub>2</sub>O)<sub>4</sub>](<i>TX</i><sub>4</sub>)<sub>2</sub> Structural Family: When Fluoroberyllate, Sulfate, and Selenate Are Full Analogs
by: Dmitri O. Charkin, et al.
Published: (2024-11-01)

Engineering the Mechanics and Thermodynamics of Ti<sub>3</sub>AlC<sub>2</sub>, Hf<sub>3</sub>AlC<sub>2</sub>, Hf<sub>3</sub>GaC<sub>2</sub>, (ZrHf)<sub>3</sub>AlC<sub>2</sub>, and (ZrHf)<sub>4</sub>AlN<sub>3</sub> MAX Phases via the Ab Initio Method
by: Adel Bandar Alruqi
Published: (2025-01-01)

Core/Shell ZnO/TiO<sub>2</sub>, SiO<sub>2</sub>/TiO<sub>2</sub>, Al<sub>2</sub>O<sub>3</sub>/TiO<sub>2</sub>, and Al<sub>1.9</sub>Co<sub>0.1</sub>O<sub>3</sub>/TiO<sub>2</sub> Nanoparticles for the Photodecomposition of Brilliant Blue E-4BA
by: Mahboubeh Dolatyari, et al.
Published: (2024-10-01)

Flavins and Flavoproteins in the Neuroimmune Landscape of Stress Sensitization and Major Depressive Disorder
by: Schrier MS, et al.
Published: (2025-01-01)