Psilocin, the Psychoactive Metabolite of Psilocybin, Modulates Select Neuroimmune Functions of Microglial Cells in a 5-HT<sub>2</sub> Receptor-Dependent Manner

Psilocin, the Psychoactive Metabolite of Psilocybin, Modulates Select Neuroimmune Functions of Microglial Cells in a 5-HT<sub>2</sub> Receptor-Dependent Manner

Neuroinflammation that is caused by microglia, the main immune cells of the brain, contributes to neurodegenerative diseases. Psychedelics, including psilocybin and lysergic acid diethylamide (LSD), possess certain anti-inflammatory properties and, therefore, should be considered as drug candidates...

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Bibliographic Details
Main Authors: Kennedy R. Wiens, Noah A. H. Brooks, Ishvin Riar, Bridget K. Greuel, Ivan A. Lindhout, Andis Klegeris
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Molecules
Subjects:
affective disorders
depression
5-hydroxytryptamine
neurodegenerative diseases
neuroprotection
phagocytic activity
Online Access:https://www.mdpi.com/1420-3049/29/21/5084
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