Impact of fresh grape juice on the pharmacokinetics of omeprazole: results of a food–drug interaction study
Grapes have been widely used for dietary ailments due to their attributed pharmacological activities. Resveratrol, the chief constituent of grapes, is responsible for their pharmacological benefits. However, apart from their beneficial effects, grapes have also recently been considered in drug inter...
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| Format: | Article |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1467805/full |
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| author | Tayyaba Iftikhar Zafar Iqbal Yasar Shah Nauman Rahim Khan Muhammad Abbas Omer Shehzad Fazal Hadi Haseeba Sardar Ali Abusharha Maria Daglia Maria Daglia Haroon Khan Haroon Khan |
| author_facet | Tayyaba Iftikhar Zafar Iqbal Yasar Shah Nauman Rahim Khan Muhammad Abbas Omer Shehzad Fazal Hadi Haseeba Sardar Ali Abusharha Maria Daglia Maria Daglia Haroon Khan Haroon Khan |
| author_sort | Tayyaba Iftikhar |
| collection | DOAJ |
| description | Grapes have been widely used for dietary ailments due to their attributed pharmacological activities. Resveratrol, the chief constituent of grapes, is responsible for their pharmacological benefits. However, apart from their beneficial effects, grapes have also recently been considered in drug interaction studies. This study investigated the pharmacokinetic profile of omeprazole administered alone compared to omeprazole administered with grape juice, with a prior intake of grape juice, for 1 continuous week. The study was conducted on two groups of healthy male volunteers [n = 12]. One group was orally administered 40 mg of omeprazole alone, while the other group was administered omeprazole with grape juice. Blood samples were analyzed for omeprazole concentration by a reverse-phase HPLC method. Co-administration of 40 mg omeprazole with grape juice significantly decreased the AUC0-t and Cmax by 32% and 34%, respectively, suggesting a role being played by grapes in the activation of P-glycoprotein and omeprazole metabolizing enzymes, including CYP3A4 and CYP2C19. In conclusion, the addition of grapes as a dietary supplement in patients taking omeprazole for the management of peptic ulcer symptoms may lead to a higher required dose of omeprazole. |
| format | Article |
| id | doaj-art-19113fd77dee4e9da04613aae7f6c6a2 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-19113fd77dee4e9da04613aae7f6c6a22024-12-04T04:32:07ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-12-011510.3389/fphar.2024.14678051467805Impact of fresh grape juice on the pharmacokinetics of omeprazole: results of a food–drug interaction studyTayyaba Iftikhar0Zafar Iqbal1Yasar Shah2Nauman Rahim Khan3Muhammad Abbas4Omer Shehzad5Fazal Hadi6Haseeba Sardar7Ali Abusharha8Maria Daglia9Maria Daglia10Haroon Khan11Haroon Khan12Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, PakistanDepartment of Pharmacy, University of Peshawar, Peshawar, PakistanDepartment of Pharmacy, Abdul Wali Khan University Mardan, Mardan, PakistanDepartment of Pharmacy, University of Science and Technology Kohat, Kohat, PakistanDepartment of Pharmacy, Abdul Wali Khan University Mardan, Mardan, PakistanDepartment of Pharmacy, Abdul Wali Khan University Mardan, Mardan, PakistanDepartment of Pharmacy, Abdul Wali Khan University Mardan, Mardan, PakistanDepartment of Pharmacy, Abdul Wali Khan University Mardan, Mardan, PakistanOptometry Department, Applied Medical Sciences Collage, King Saud University, Riyadh, Saudi ArabiaDepartment of Pharmacy, University of Naples Federico II, Naples, ItalyInternational Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, ChinaDepartment of Pharmacy, Abdul Wali Khan University Mardan, Mardan, PakistanDepartment of Pharmacy, Korea University, Sejong, Republic of KoreaGrapes have been widely used for dietary ailments due to their attributed pharmacological activities. Resveratrol, the chief constituent of grapes, is responsible for their pharmacological benefits. However, apart from their beneficial effects, grapes have also recently been considered in drug interaction studies. This study investigated the pharmacokinetic profile of omeprazole administered alone compared to omeprazole administered with grape juice, with a prior intake of grape juice, for 1 continuous week. The study was conducted on two groups of healthy male volunteers [n = 12]. One group was orally administered 40 mg of omeprazole alone, while the other group was administered omeprazole with grape juice. Blood samples were analyzed for omeprazole concentration by a reverse-phase HPLC method. Co-administration of 40 mg omeprazole with grape juice significantly decreased the AUC0-t and Cmax by 32% and 34%, respectively, suggesting a role being played by grapes in the activation of P-glycoprotein and omeprazole metabolizing enzymes, including CYP3A4 and CYP2C19. In conclusion, the addition of grapes as a dietary supplement in patients taking omeprazole for the management of peptic ulcer symptoms may lead to a higher required dose of omeprazole.https://www.frontiersin.org/articles/10.3389/fphar.2024.1467805/fullfood–drug interactionsomeprazolegrape juicepharmacokineticstherapeutic outcome |
| spellingShingle | Tayyaba Iftikhar Zafar Iqbal Yasar Shah Nauman Rahim Khan Muhammad Abbas Omer Shehzad Fazal Hadi Haseeba Sardar Ali Abusharha Maria Daglia Maria Daglia Haroon Khan Haroon Khan Impact of fresh grape juice on the pharmacokinetics of omeprazole: results of a food–drug interaction study Frontiers in Pharmacology food–drug interactions omeprazole grape juice pharmacokinetics therapeutic outcome |
| title | Impact of fresh grape juice on the pharmacokinetics of omeprazole: results of a food–drug interaction study |
| title_full | Impact of fresh grape juice on the pharmacokinetics of omeprazole: results of a food–drug interaction study |
| title_fullStr | Impact of fresh grape juice on the pharmacokinetics of omeprazole: results of a food–drug interaction study |
| title_full_unstemmed | Impact of fresh grape juice on the pharmacokinetics of omeprazole: results of a food–drug interaction study |
| title_short | Impact of fresh grape juice on the pharmacokinetics of omeprazole: results of a food–drug interaction study |
| title_sort | impact of fresh grape juice on the pharmacokinetics of omeprazole results of a food drug interaction study |
| topic | food–drug interactions omeprazole grape juice pharmacokinetics therapeutic outcome |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1467805/full |
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