Strategies for specific multimodal imaging of cancer-associated fibroblasts and applications in theranostics of cancer
Fibroblast activating protein (FAP) is up-regulated in cancer-associated fibroblasts (CAFs) of more than 90 % of tumor microenvironment and also highly expressed on the surface of multiple tumor cells like glioblastoma, which can be used as a specific target for tumor diagnosis and treatment. At pre...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424004812 |
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| author | Li Wen Chengxue He Yanhui Guo Nina Zhou Xiangxi Meng Yuwen Chen Cheng Ma Hua Zhu Zhi Yang Lei Xia |
| author_facet | Li Wen Chengxue He Yanhui Guo Nina Zhou Xiangxi Meng Yuwen Chen Cheng Ma Hua Zhu Zhi Yang Lei Xia |
| author_sort | Li Wen |
| collection | DOAJ |
| description | Fibroblast activating protein (FAP) is up-regulated in cancer-associated fibroblasts (CAFs) of more than 90 % of tumor microenvironment and also highly expressed on the surface of multiple tumor cells like glioblastoma, which can be used as a specific target for tumor diagnosis and treatment. At present, small-molecule radiotracer targeting FAP with high specificity exhibit limited functionality, which hinders the integration of theranostics as well as multifunctionality. In this work, we have engineered a multifunctional nanoplatform utilizing organic melanin nanoparticles that specifically targets FAP, facilitating both multimodal imaging and synergistic therapeutic applications. This nanoplatform can perform positron emission tomography (PET), magnetic resonance imaging (MRI) and photoacoustic imaging (PAI) with strong near infrared absorption and metal chelating ability, achieving efficiently targeting accumulation and display long retention in the tumor region. Meanwhile, 131I-labeled nanoplatform for targeted radioisotope therapy (TRT) and photothermal therapy (PTT) were significantly suppressed tumor growth in glioblastoma xenograft models without obvious side effects. These results demonstrated that this novel nanoparticles-based theranostics nanoplatform can effectively enhance multimodal imaging and targeted radionuclide-photothermal synergistic therapy for solid tumors with FAP expression. |
| format | Article |
| id | doaj-art-042118400915482fb926992d42903939 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-042118400915482fb926992d429039392025-01-17T04:52:10ZengElsevierMaterials Today Bio2590-00642025-02-0130101420Strategies for specific multimodal imaging of cancer-associated fibroblasts and applications in theranostics of cancerLi Wen0Chengxue He1Yanhui Guo2Nina Zhou3Xiangxi Meng4Yuwen Chen5Cheng Ma6Hua Zhu7Zhi Yang8Lei Xia9Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, China; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key Laboratory of Molecular Imaging, Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, ChinaDepartment of Radiology, Peking University Third Hospital, Beijing, 100088, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, ChinaDepartment of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Tsinghua University, Beijing, 100084, China; Institute for Intelligent Healthcare, Tsinghua University, Beijing, 100084, ChinaDepartment of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Tsinghua University, Beijing, 100084, China; Institute for Intelligent Healthcare, Tsinghua University, Beijing, 100084, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, China; Corresponding author.Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, China; Corresponding author.Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, China; Corresponding author.Fibroblast activating protein (FAP) is up-regulated in cancer-associated fibroblasts (CAFs) of more than 90 % of tumor microenvironment and also highly expressed on the surface of multiple tumor cells like glioblastoma, which can be used as a specific target for tumor diagnosis and treatment. At present, small-molecule radiotracer targeting FAP with high specificity exhibit limited functionality, which hinders the integration of theranostics as well as multifunctionality. In this work, we have engineered a multifunctional nanoplatform utilizing organic melanin nanoparticles that specifically targets FAP, facilitating both multimodal imaging and synergistic therapeutic applications. This nanoplatform can perform positron emission tomography (PET), magnetic resonance imaging (MRI) and photoacoustic imaging (PAI) with strong near infrared absorption and metal chelating ability, achieving efficiently targeting accumulation and display long retention in the tumor region. Meanwhile, 131I-labeled nanoplatform for targeted radioisotope therapy (TRT) and photothermal therapy (PTT) were significantly suppressed tumor growth in glioblastoma xenograft models without obvious side effects. These results demonstrated that this novel nanoparticles-based theranostics nanoplatform can effectively enhance multimodal imaging and targeted radionuclide-photothermal synergistic therapy for solid tumors with FAP expression.http://www.sciencedirect.com/science/article/pii/S2590006424004812Fibroblast activating proteinMelanin nanoparticlesMultimodal imagingTheranosticsRadioisotope therapy |
| spellingShingle | Li Wen Chengxue He Yanhui Guo Nina Zhou Xiangxi Meng Yuwen Chen Cheng Ma Hua Zhu Zhi Yang Lei Xia Strategies for specific multimodal imaging of cancer-associated fibroblasts and applications in theranostics of cancer Materials Today Bio Fibroblast activating protein Melanin nanoparticles Multimodal imaging Theranostics Radioisotope therapy |
| title | Strategies for specific multimodal imaging of cancer-associated fibroblasts and applications in theranostics of cancer |
| title_full | Strategies for specific multimodal imaging of cancer-associated fibroblasts and applications in theranostics of cancer |
| title_fullStr | Strategies for specific multimodal imaging of cancer-associated fibroblasts and applications in theranostics of cancer |
| title_full_unstemmed | Strategies for specific multimodal imaging of cancer-associated fibroblasts and applications in theranostics of cancer |
| title_short | Strategies for specific multimodal imaging of cancer-associated fibroblasts and applications in theranostics of cancer |
| title_sort | strategies for specific multimodal imaging of cancer associated fibroblasts and applications in theranostics of cancer |
| topic | Fibroblast activating protein Melanin nanoparticles Multimodal imaging Theranostics Radioisotope therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424004812 |
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