Tremelimumab plus durvalumab combined to metronomic oral vinorelbine: Results from the breast cancer cohort of the phase II MOVIE study

Tremelimumab plus durvalumab combined to metronomic oral vinorelbine: Results from the breast cancer cohort of the phase II MOVIE study

Purpose: MOVIE assessed the enhancement of immunotherapy activity in advanced breast cancer (BC) tumors with metronomic chemotherapy associated to dual ICI combination. Methods: MOVIE was a national, multicenter, open-label, phase I/II, non-randomized. It tested the antitumor activity and safety of...

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Main Authors: T. De La Motte Rouge, J.-S. Frenel, C. Cropet, E. Borcoman, A. Hervieu, G. Emile, P. Augereau, E. Charafe, F. Legrand, E. Dassé, A. Gonçalves
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Breast
Subjects:
Advanced breast cancer (advanced BC)
Anti-PD-1/PD-L1
Anti-CTLA-4
Immune checkpoint inhibitor (ICI)
Metronomic chemotherapy (MC)
Online Access:http://www.sciencedirect.com/science/article/pii/S0960977625005661
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