Peripheral contributions to resting state brain dynamics
Abstract The correlational structure of brain activity dynamics in the absence of stimuli or behavior is often taken to reveal intrinsic properties of neural function. To test the limits of this assumption, we analyzed peripheral contributions to resting state activity measured by fMRI in unanesthet...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55064-6 |
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| author | Sarah Bricault Miranda Dawson Jiyoung Lee Mitul Desai Miriam Schwalm Kevin Sunho Chung Elizabeth DeTienne Erinn Fagan Nan Li Andrew Becker Sureshkumar Muthupalani Jan-Philipp Fränken Dimitris A. Pinotsis Alan Jasanoff |
| author_facet | Sarah Bricault Miranda Dawson Jiyoung Lee Mitul Desai Miriam Schwalm Kevin Sunho Chung Elizabeth DeTienne Erinn Fagan Nan Li Andrew Becker Sureshkumar Muthupalani Jan-Philipp Fränken Dimitris A. Pinotsis Alan Jasanoff |
| author_sort | Sarah Bricault |
| collection | DOAJ |
| description | Abstract The correlational structure of brain activity dynamics in the absence of stimuli or behavior is often taken to reveal intrinsic properties of neural function. To test the limits of this assumption, we analyzed peripheral contributions to resting state activity measured by fMRI in unanesthetized, chemically immobilized male rats that emulate human neuroimaging conditions. We find that perturbation of somatosensory input channels modifies correlation strengths that relate somatosensory areas both to one another and to higher-order brain regions, despite the absence of ostensible stimuli or movements. Resting state effects are mediated by the same peripheral and thalamic structures that relay responses to overt sensory stimuli. The impact of basal peripheral input is reduced in a rat model of autism, which displays both lower somatosensory functional connectivity and insensitivity to vibrissa inactivation. These results demonstrate the influence of extrinsic influences on resting state brain phenotypes in health and disease. |
| format | Article |
| id | doaj-art-ffefc64d3727496b921ffe5ea25162ed |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-ffefc64d3727496b921ffe5ea25162ed2025-01-05T12:36:05ZengNature PortfolioNature Communications2041-17232024-12-0115111510.1038/s41467-024-55064-6Peripheral contributions to resting state brain dynamicsSarah Bricault0Miranda Dawson1Jiyoung Lee2Mitul Desai3Miriam Schwalm4Kevin Sunho Chung5Elizabeth DeTienne6Erinn Fagan7Nan Li8Andrew Becker9Sureshkumar Muthupalani10Jan-Philipp Fränken11Dimitris A. Pinotsis12Alan Jasanoff13Department of Biological Engineering, Massachusetts Institute of TechnologyDepartment of Biological Engineering, Massachusetts Institute of TechnologyDepartment of Neurobiology, Wellesley CollegeDepartment of Biological Engineering, Massachusetts Institute of TechnologyDepartment of Biological Engineering, Massachusetts Institute of TechnologyDepartment of Biological Engineering, Massachusetts Institute of TechnologyDepartment of Electrical Engineering & Computer Science, Massachusetts Institute of TechnologyDepartment of Biological Engineering, Massachusetts Institute of TechnologyDepartment of Biological Engineering, Massachusetts Institute of TechnologyDepartment of Biological Engineering, Massachusetts Institute of TechnologyDivision of Comparative Medicine, Massachusetts Institute of TechnologyDepartment of Psychology, University of EdinburghCenter for Mathematical Neuroscience and Psychology, Department of Psychology, City, University of LondonDepartment of Biological Engineering, Massachusetts Institute of TechnologyAbstract The correlational structure of brain activity dynamics in the absence of stimuli or behavior is often taken to reveal intrinsic properties of neural function. To test the limits of this assumption, we analyzed peripheral contributions to resting state activity measured by fMRI in unanesthetized, chemically immobilized male rats that emulate human neuroimaging conditions. We find that perturbation of somatosensory input channels modifies correlation strengths that relate somatosensory areas both to one another and to higher-order brain regions, despite the absence of ostensible stimuli or movements. Resting state effects are mediated by the same peripheral and thalamic structures that relay responses to overt sensory stimuli. The impact of basal peripheral input is reduced in a rat model of autism, which displays both lower somatosensory functional connectivity and insensitivity to vibrissa inactivation. These results demonstrate the influence of extrinsic influences on resting state brain phenotypes in health and disease.https://doi.org/10.1038/s41467-024-55064-6 |
| spellingShingle | Sarah Bricault Miranda Dawson Jiyoung Lee Mitul Desai Miriam Schwalm Kevin Sunho Chung Elizabeth DeTienne Erinn Fagan Nan Li Andrew Becker Sureshkumar Muthupalani Jan-Philipp Fränken Dimitris A. Pinotsis Alan Jasanoff Peripheral contributions to resting state brain dynamics Nature Communications |
| title | Peripheral contributions to resting state brain dynamics |
| title_full | Peripheral contributions to resting state brain dynamics |
| title_fullStr | Peripheral contributions to resting state brain dynamics |
| title_full_unstemmed | Peripheral contributions to resting state brain dynamics |
| title_short | Peripheral contributions to resting state brain dynamics |
| title_sort | peripheral contributions to resting state brain dynamics |
| url | https://doi.org/10.1038/s41467-024-55064-6 |
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