Genome‐scale metabolic modeling reveals key features of a minimal gene set

Genome‐scale metabolic modeling reveals key features of a minimal gene set

Abstract Mesoplasma florum, a fast‐growing near‐minimal organism, is a compelling model to explore rational genome designs. Using sequence and structural homology, the set of metabolic functions its genome encodes was identified, allowing the reconstruction of a metabolic network representing ˜ 30%...

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Main Authors: Jean‐Christophe Lachance, Dominick Matteau, Joëlle Brodeur, Colton J Lloyd, Nathan Mih, Zachary A King, Thomas F Knight, Adam M Feist, Jonathan M Monk, Bernhard O Palsson, Pierre‐Étienne Jacques, Sébastien Rodrigue
Format: Article
Language:English
Published: Springer Nature 2021-07-01
Series:Molecular Systems Biology
Subjects:
genome design
genome‐scale models
Mesoplasma florum
minimal cells
synthetic biology
Online Access:https://doi.org/10.15252/msb.202010099
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https://doi.org/10.15252/msb.202010099

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