Inhibition of Unc119b improves insulin sensitivity through potentiation of Rac1 activation in skeletal muscle and brown adipose tissue

Inhibition of Unc119b improves insulin sensitivity through potentiation of Rac1 activation in skeletal muscle and brown adipose tissue

Objectives: A hallmark of type II diabetes is an impairment of the glucose transporter GLUT4 translocation to the plasma membrane of specialized cells in response to insulin. Identifying mechanisms involved in this defect is critical to developing treatments that restore insulin sensitivity. We prev...

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Bibliographic Details
Main Authors: Ayushi Mittal, Paul Buscaglia, Dhiraj Srivastava, Nikolai O. Artemyev, Julien A. Sebag
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Molecular Metabolism
Subjects:
Diabetes
GLUT4 translocation
Unc119b
Rac1
Insulin sensitivity
Glucose tolerance
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825001371
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