Safety, tolerability and immunogenicity of a condensed, multi-dose prime regimen of PfSPZ Vaccine for the prevention of Plasmodium falciparum malaria infection

Safety, tolerability and immunogenicity of a condensed, multi-dose prime regimen of PfSPZ Vaccine for the prevention of Plasmodium falciparum malaria infection

Abstract Background The World Health Organization (WHO) has called for new malaria vaccines with > 90% efficacy against Plasmodium falciparum infection to expand the anti-disease benefit provided by the RTS,S/AS01 and R21/Matrix M subunit vaccines currently administered to infants and young child...

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Main Authors: Andrea A. Berry, Thomas L. Richie, L. W. Preston Church, Matthew B. Laurens, Colleen Boyce, Natasha KC, Sudhaunshu Joshi, Abra Rachida Koudjra, Lauryn Butler, Mei-Chun Chen, Yonas Abebe, Tooba Murshedkar, Eric R. James, Peter F. Billingsley, B. Kim Lee Sim, Stephen L. Hoffman, Kirsten E. Lyke
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Malaria Journal
Subjects:
PfSPZ
Vaccines
Plasmodium falciparum
Malaria
Safety
Immunogenicity
Online Access:https://doi.org/10.1186/s12936-025-05299-5
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https://doi.org/10.1186/s12936-025-05299-5

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