Association of the SNPs in CCL2 and CXCL12 genes with the susceptibility to breast cancer: a case-control study in China
BackgroundChemokines are well-known for playing an essential role in the development of cancer. However, the association between SNPs in the CCL2 and CXCL12 genes and the susceptibility to breast cancer remains unclear.MethodsA case-control study was conducted in southeast China, including 1855 brea...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-12-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1475979/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846140814388887552 |
|---|---|
| author | Duanchong Zhao Xingxing Yu Hongli Huang Shuqing Zou Pingxiu Zhu Yuxiang Lin Yuxiang Lin Mengjie Song Fangmeng Fu Fangmeng Fu Haomin Yang Haomin Yang |
| author_facet | Duanchong Zhao Xingxing Yu Hongli Huang Shuqing Zou Pingxiu Zhu Yuxiang Lin Yuxiang Lin Mengjie Song Fangmeng Fu Fangmeng Fu Haomin Yang Haomin Yang |
| author_sort | Duanchong Zhao |
| collection | DOAJ |
| description | BackgroundChemokines are well-known for playing an essential role in the development of cancer. However, the association between SNPs in the CCL2 and CXCL12 genes and the susceptibility to breast cancer remains unclear.MethodsA case-control study was conducted in southeast China, including 1855 breast cancer patients and 1838 cancer-free controls. The association between single nucleotide polymorphisms (SNPs) in the CCL2 and CXCL12 genes and the susceptibility to breast cancer was investigated using logistic regression models. The association between plasma CCL2 and CXCL12 with breast cancer was further examined in 72 patients and 75 controls.ResultsThe CXCL12 SNP rs3740085 was associated with breast cancer in the additive model (OR=1.15, 95%CI=1.01-1.32), particularly in postmenopausal women. The association between rs1024611 in CCL2 and breast cancer was only found in women with a BMI of ≥24kg/m2. SNPs in the CCL2 gene were mainly associated with PR-positive breast cancer, whereas rs1144471 in CXCL12 was associated with ER-negative (OR=0.43, 95% CI=0.23-0.84), PR-negative (OR=0.38, 95% CI=0.19-0.74), and HER-2-positive (OR=1.27, 95% CI=1.03-1.56) breast cancer. The interaction between rs1801157 and rs3740085 in CXCL12 SNPs was statistically significant, and rs3740085 was also associated with breast cancer survival. Additionally, we found a strong association between plasma CXCL12 and breast cancer.ConclusionCCL2 and CXCL12 SNPs are associated with breast cancer susceptibility in overweight and postmenopausal women, and the effect varies according to subtypes. The interaction of SNPs within CXCL12 gene and the association with breast cancer survival further suggest potential targets for improved risk assessment and treatment strategies. |
| format | Article |
| id | doaj-art-ff1fc5b8b62440b09fd21d6d6a14afba |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-ff1fc5b8b62440b09fd21d6d6a14afba2024-12-05T05:10:22ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-12-011410.3389/fonc.2024.14759791475979Association of the SNPs in CCL2 and CXCL12 genes with the susceptibility to breast cancer: a case-control study in ChinaDuanchong Zhao0Xingxing Yu1Hongli Huang2Shuqing Zou3Pingxiu Zhu4Yuxiang Lin5Yuxiang Lin6Mengjie Song7Fangmeng Fu8Fangmeng Fu9Haomin Yang10Haomin Yang11Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, ChinaDepartment of Operation and Supervision, Jining Customs of the People’s Republic of China, Jining, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, ChinaDepartment of Breast Surgery, Fujian Medical University Union Hospital, Fuzhou, ChinaBreast Cancer Institute, Fujian Medical University, Fuzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, ChinaDepartment of Breast Surgery, Fujian Medical University Union Hospital, Fuzhou, ChinaBreast Cancer Institute, Fujian Medical University, Fuzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, ChinaDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenBackgroundChemokines are well-known for playing an essential role in the development of cancer. However, the association between SNPs in the CCL2 and CXCL12 genes and the susceptibility to breast cancer remains unclear.MethodsA case-control study was conducted in southeast China, including 1855 breast cancer patients and 1838 cancer-free controls. The association between single nucleotide polymorphisms (SNPs) in the CCL2 and CXCL12 genes and the susceptibility to breast cancer was investigated using logistic regression models. The association between plasma CCL2 and CXCL12 with breast cancer was further examined in 72 patients and 75 controls.ResultsThe CXCL12 SNP rs3740085 was associated with breast cancer in the additive model (OR=1.15, 95%CI=1.01-1.32), particularly in postmenopausal women. The association between rs1024611 in CCL2 and breast cancer was only found in women with a BMI of ≥24kg/m2. SNPs in the CCL2 gene were mainly associated with PR-positive breast cancer, whereas rs1144471 in CXCL12 was associated with ER-negative (OR=0.43, 95% CI=0.23-0.84), PR-negative (OR=0.38, 95% CI=0.19-0.74), and HER-2-positive (OR=1.27, 95% CI=1.03-1.56) breast cancer. The interaction between rs1801157 and rs3740085 in CXCL12 SNPs was statistically significant, and rs3740085 was also associated with breast cancer survival. Additionally, we found a strong association between plasma CXCL12 and breast cancer.ConclusionCCL2 and CXCL12 SNPs are associated with breast cancer susceptibility in overweight and postmenopausal women, and the effect varies according to subtypes. The interaction of SNPs within CXCL12 gene and the association with breast cancer survival further suggest potential targets for improved risk assessment and treatment strategies.https://www.frontiersin.org/articles/10.3389/fonc.2024.1475979/fullSNPCCL2CXCL12breast cancerchemokine |
| spellingShingle | Duanchong Zhao Xingxing Yu Hongli Huang Shuqing Zou Pingxiu Zhu Yuxiang Lin Yuxiang Lin Mengjie Song Fangmeng Fu Fangmeng Fu Haomin Yang Haomin Yang Association of the SNPs in CCL2 and CXCL12 genes with the susceptibility to breast cancer: a case-control study in China Frontiers in Oncology SNP CCL2 CXCL12 breast cancer chemokine |
| title | Association of the SNPs in CCL2 and CXCL12 genes with the susceptibility to breast cancer: a case-control study in China |
| title_full | Association of the SNPs in CCL2 and CXCL12 genes with the susceptibility to breast cancer: a case-control study in China |
| title_fullStr | Association of the SNPs in CCL2 and CXCL12 genes with the susceptibility to breast cancer: a case-control study in China |
| title_full_unstemmed | Association of the SNPs in CCL2 and CXCL12 genes with the susceptibility to breast cancer: a case-control study in China |
| title_short | Association of the SNPs in CCL2 and CXCL12 genes with the susceptibility to breast cancer: a case-control study in China |
| title_sort | association of the snps in ccl2 and cxcl12 genes with the susceptibility to breast cancer a case control study in china |
| topic | SNP CCL2 CXCL12 breast cancer chemokine |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1475979/full |
| work_keys_str_mv | AT duanchongzhao associationofthesnpsinccl2andcxcl12geneswiththesusceptibilitytobreastcanceracasecontrolstudyinchina AT xingxingyu associationofthesnpsinccl2andcxcl12geneswiththesusceptibilitytobreastcanceracasecontrolstudyinchina AT honglihuang associationofthesnpsinccl2andcxcl12geneswiththesusceptibilitytobreastcanceracasecontrolstudyinchina AT shuqingzou associationofthesnpsinccl2andcxcl12geneswiththesusceptibilitytobreastcanceracasecontrolstudyinchina AT pingxiuzhu associationofthesnpsinccl2andcxcl12geneswiththesusceptibilitytobreastcanceracasecontrolstudyinchina AT yuxianglin associationofthesnpsinccl2andcxcl12geneswiththesusceptibilitytobreastcanceracasecontrolstudyinchina AT yuxianglin associationofthesnpsinccl2andcxcl12geneswiththesusceptibilitytobreastcanceracasecontrolstudyinchina AT mengjiesong associationofthesnpsinccl2andcxcl12geneswiththesusceptibilitytobreastcanceracasecontrolstudyinchina AT fangmengfu associationofthesnpsinccl2andcxcl12geneswiththesusceptibilitytobreastcanceracasecontrolstudyinchina AT fangmengfu associationofthesnpsinccl2andcxcl12geneswiththesusceptibilitytobreastcanceracasecontrolstudyinchina AT haominyang associationofthesnpsinccl2andcxcl12geneswiththesusceptibilitytobreastcanceracasecontrolstudyinchina AT haominyang associationofthesnpsinccl2andcxcl12geneswiththesusceptibilitytobreastcanceracasecontrolstudyinchina |