Visualization of argininosuccinate synthetase by in silico analysis: novel insights into citrullinemia type I disorders

Visualization of argininosuccinate synthetase by in silico analysis: novel insights into citrullinemia type I disorders

BackgroundCitrullinemia type I disorders (CTLN1) is a genetic metabolic disease caused by argininosuccinate synthetase (ASS1) gene mutation. To date, the human genome mutation database has documented over 100 variants of the ASS1 gene. This study reported a novel deletion-insertion variant of ASS1 g...

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Bibliographic Details
Main Authors: Xia Gu, Wenhui Mo, Guiying Zhuang, Congcong Shi, Tao Wei, Jinze Zhang, Chiaowen Tu, Yao Cai, Biwen Liao, Hu Hao
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
citrullinemia type I
argininosuccinate synthetase
deletion-insertion variants
in silico analysis
molecular dynamics simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2024.1482773/full
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https://www.frontiersin.org/articles/10.3389/fmolb.2024.1482773/full

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