Universal penalized regression (Elastic-net) model with differentially methylated promoters for oral cancer prediction

Universal penalized regression (Elastic-net) model with differentially methylated promoters for oral cancer prediction

Abstract Background DNA methylation showed notable potential to act as a diagnostic marker in many cancers. Many studies proposed DNA methylation biomarker in OSCC detection, while most of these studies are limited to specific cohorts or geographical location. However, the generalizability of DNA me...

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Main Authors: Shantanab Das, Saikat Karuri, Joyeeta Chakraborty, Baidehi Basu, Aditi Chandra, S. Aravindan, Anirvan Chakraborty, Debashis Paul, Jay Gopal Ray, Matt Lechner, Stephan Beck, Andrew E. Teschendorff, Raghunath Chatterjee
Format: Article
Language:English
Published: BMC 2024-09-01
Series:European Journal of Medical Research
Subjects:
DNA methylation
Linear regression techniques
HNSCC
Droplet digital PCR
Methylation-sensitive restriction enzyme
Oral squamous cell carcinoma
Online Access:https://doi.org/10.1186/s40001-024-02047-4
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https://doi.org/10.1186/s40001-024-02047-4

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