Transcriptomics as a predictor of biopharmaceutically favourable glycan profiles

N-glycosylation plays a crucial role in defining the pharmacological properties and efficacy of therapeutic proteins, commonly referred to as biologics. The inherent complexity and lack of a templated process in glycosylation leads to a wide variation in glycan structures, posing significant challen...

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Bibliographic Details
Main Authors: Ben West, Pavlos Kotidis, Alena Istrate, Daniele Perna, Gary Finka, A. Jamie Wood, Daniel Ungar
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Cell and Developmental Biology
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Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1504381/full
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