Multicolored sequential resonance energy transfer for detection of simultaneous ligand binding at G protein-coupled receptors

Multicolored sequential resonance energy transfer for detection of simultaneous ligand binding at G protein-coupled receptors

Abstract G protein coupled-receptors (GPCRs) are the largest family of signalling proteins and highly successful drug targets. Most GPCR targeting drugs interact with a binding pocket for the natural ligand of the receptor, typically near the extracellular region of the transmembrane domains. Advanc...

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Main Authors: Alice Valentini, Bethany Dibnah, Marija Ciba, Elaine M. Duncan, Asmita Manandhar, Bethany Strellis, Luca Vita, Olivia Lucianno, Conor Massey, Sophie Coe, Trond Ulven, Brian D. Hudson, Elisabeth Rexen Ulven
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61690-5
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https://doi.org/10.1038/s41467-025-61690-5

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