CXCL14 in prostate cancer: complex interactions in the tumor microenvironment and future prospects
Abstract CXCL14 is a highly conserved chemokine expressed in various cell types, playing crucial roles in both physiological and pathological processes, including immune regulation and tumorigenesis. Recently, the role of CXCL14 in tumors has attracted considerable attention. However, previous pan-c...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-024-06022-9 |
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| author | Lei Tang Xin Chen Jianquan Hou Xuedong Wei |
| author_facet | Lei Tang Xin Chen Jianquan Hou Xuedong Wei |
| author_sort | Lei Tang |
| collection | DOAJ |
| description | Abstract CXCL14 is a highly conserved chemokine expressed in various cell types, playing crucial roles in both physiological and pathological processes, including immune regulation and tumorigenesis. Recently, the role of CXCL14 in tumors has attracted considerable attention. However, previous pan-cancer studies have reported inconsistencies regarding the effects of CXCL14 on tumors, particularly concerning its expression levels in tumor tissues and its influence on various phenotypes of cancer cells. This variability is believed to stem from the context-dependent nature of CXCL14, as different sources of CXCL14 and its secretion within distinct tumor microenvironments may mediate diverse biological effects. Such phenomena have also been observed in prostate cancer research. Despite a foundational understanding of CXCL14 in prostate cancer, there remains a lack of comprehensive reviews summarizing the specific roles of this chemokine and systematically analyzing the reasons behind its complex effects. Therefore, this article aims to discuss the role of CXCL14 in the tumor microenvironment of prostate cancer and explore future research directions and potential applications. |
| format | Article |
| id | doaj-art-feb216823e8f4012a2e530d8fd99a7b0 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-feb216823e8f4012a2e530d8fd99a7b02025-01-05T12:44:32ZengBMCJournal of Translational Medicine1479-58762025-01-0123111410.1186/s12967-024-06022-9CXCL14 in prostate cancer: complex interactions in the tumor microenvironment and future prospectsLei Tang0Xin Chen1Jianquan Hou2Xuedong Wei3Department of Urology, Dushu Lake Hospital Affiliated to Soochow UniversityDepartment of Urology, Dushu Lake Hospital Affiliated to Soochow UniversityDepartment of Urology, Dushu Lake Hospital Affiliated to Soochow UniversityDepartment of Urology, The First Affiliated Hospital of Soochow UniversityAbstract CXCL14 is a highly conserved chemokine expressed in various cell types, playing crucial roles in both physiological and pathological processes, including immune regulation and tumorigenesis. Recently, the role of CXCL14 in tumors has attracted considerable attention. However, previous pan-cancer studies have reported inconsistencies regarding the effects of CXCL14 on tumors, particularly concerning its expression levels in tumor tissues and its influence on various phenotypes of cancer cells. This variability is believed to stem from the context-dependent nature of CXCL14, as different sources of CXCL14 and its secretion within distinct tumor microenvironments may mediate diverse biological effects. Such phenomena have also been observed in prostate cancer research. Despite a foundational understanding of CXCL14 in prostate cancer, there remains a lack of comprehensive reviews summarizing the specific roles of this chemokine and systematically analyzing the reasons behind its complex effects. Therefore, this article aims to discuss the role of CXCL14 in the tumor microenvironment of prostate cancer and explore future research directions and potential applications.https://doi.org/10.1186/s12967-024-06022-9Prostate cancerChemokinesCXCL14Tumor microenvironment |
| spellingShingle | Lei Tang Xin Chen Jianquan Hou Xuedong Wei CXCL14 in prostate cancer: complex interactions in the tumor microenvironment and future prospects Journal of Translational Medicine Prostate cancer Chemokines CXCL14 Tumor microenvironment |
| title | CXCL14 in prostate cancer: complex interactions in the tumor microenvironment and future prospects |
| title_full | CXCL14 in prostate cancer: complex interactions in the tumor microenvironment and future prospects |
| title_fullStr | CXCL14 in prostate cancer: complex interactions in the tumor microenvironment and future prospects |
| title_full_unstemmed | CXCL14 in prostate cancer: complex interactions in the tumor microenvironment and future prospects |
| title_short | CXCL14 in prostate cancer: complex interactions in the tumor microenvironment and future prospects |
| title_sort | cxcl14 in prostate cancer complex interactions in the tumor microenvironment and future prospects |
| topic | Prostate cancer Chemokines CXCL14 Tumor microenvironment |
| url | https://doi.org/10.1186/s12967-024-06022-9 |
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