CCDC28A deficiency causes head-tail coupling defects and immotility in murine spermatozoa

CCDC28A deficiency causes head-tail coupling defects and immotility in murine spermatozoa

Abstract Male infertility presents a substantial challenge in reproductive medicine, often attributed to impaired sperm motility. The present study investigates the role of CCDC28A, a protein expressed specifically in male germ cells, whose paralog CCDC28B has been implicated in ciliogenesis. We ide...

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Bibliographic Details
Main Authors: Nena Stojanovic, Rosario Ortiz Hernández, Nayeli Torres Ramírez, Olga Margarita Echeverría Martínez, Abrahan Hernández Hernández, Hiroki Shibuya
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
CCDC28A
CCDC28B
Flagellum
Spermiogenesis
Sperm
Head-tail coupling apparatus (HTCA)
Online Access:https://doi.org/10.1038/s41598-024-78453-9
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https://doi.org/10.1038/s41598-024-78453-9

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