Economic analysis of buffer preparation strategy for single-use bioprocessing of monoclonal antibodies
The total cost of buffer preparation was analyzed for an existing single-use mAbs downstream processing facility. The cost effectiveness of outsourcing the liquid buffer as a ready-to-use and/or concentrate was examined by comparing a traditional made-in-house buffer from solid ingredients. The anal...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-11-01
|
| Series: | EFB Bioeconomy Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266704102400003X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846164512244236288 |
|---|---|
| author | Takao ITO Ann-Kathrin Uebele Takashi Nihei Koichi Yamamoto Naoto Watanabe Yoshiyuki Tokieda Masaki Okada |
| author_facet | Takao ITO Ann-Kathrin Uebele Takashi Nihei Koichi Yamamoto Naoto Watanabe Yoshiyuki Tokieda Masaki Okada |
| author_sort | Takao ITO |
| collection | DOAJ |
| description | The total cost of buffer preparation was analyzed for an existing single-use mAbs downstream processing facility. The cost effectiveness of outsourcing the liquid buffer as a ready-to-use and/or concentrate was examined by comparing a traditional made-in-house buffer from solid ingredients. The analysis show the combination of made-in-house buffer and concentrate buffer provides the greatest cost advantages. Ready-to-use buffers are more effective for improved facility footprint and provide cost benefits when in-house labor and consumables exceeds the cost of outsourcing. From the calculation of the cost of labor and number of pallets, although the difference in labor costs was small between the various buffer preparation methods, the use of concentrated buffers reduced both the total number of pallets and overall costs. When a new in-line dilution system is installed, a high facility utilization rate of at least ten preparations per year is required to leverage the cost savings from single-use consumables. |
| format | Article |
| id | doaj-art-fe9fce1aa0b546b281f27078befeaaa5 |
| institution | Kabale University |
| issn | 2667-0410 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EFB Bioeconomy Journal |
| spelling | doaj-art-fe9fce1aa0b546b281f27078befeaaa52024-11-18T04:33:57ZengElsevierEFB Bioeconomy Journal2667-04102024-11-014100065Economic analysis of buffer preparation strategy for single-use bioprocessing of monoclonal antibodiesTakao ITO0Ann-Kathrin Uebele1Takashi Nihei2Koichi Yamamoto3Naoto Watanabe4Yoshiyuki Tokieda5Masaki Okada6Merck Ltd. (An Affiliate of Merck KGaA, Darmstadt, Germany), Tokyo Japan; Corresponding author.Merck KgaA, Darmstadt, GermanyTakeda Pharmaceutical Co., Ltd., Fujisawa JapanKyowa Kirin Co., Ltd., Takasaki JapanAsahi Kasei Medical Co., Ltd., Tokyo JapanKM Biologics Co., Ltd. Kikuchi JapanLife Scientia Ltd., Yokohama JapanThe total cost of buffer preparation was analyzed for an existing single-use mAbs downstream processing facility. The cost effectiveness of outsourcing the liquid buffer as a ready-to-use and/or concentrate was examined by comparing a traditional made-in-house buffer from solid ingredients. The analysis show the combination of made-in-house buffer and concentrate buffer provides the greatest cost advantages. Ready-to-use buffers are more effective for improved facility footprint and provide cost benefits when in-house labor and consumables exceeds the cost of outsourcing. From the calculation of the cost of labor and number of pallets, although the difference in labor costs was small between the various buffer preparation methods, the use of concentrated buffers reduced both the total number of pallets and overall costs. When a new in-line dilution system is installed, a high facility utilization rate of at least ten preparations per year is required to leverage the cost savings from single-use consumables.http://www.sciencedirect.com/science/article/pii/S266704102400003XConcentrated bufferReady-to-use bufferDownstream processingMonoclonal antibodyIn-line dilution |
| spellingShingle | Takao ITO Ann-Kathrin Uebele Takashi Nihei Koichi Yamamoto Naoto Watanabe Yoshiyuki Tokieda Masaki Okada Economic analysis of buffer preparation strategy for single-use bioprocessing of monoclonal antibodies EFB Bioeconomy Journal Concentrated buffer Ready-to-use buffer Downstream processing Monoclonal antibody In-line dilution |
| title | Economic analysis of buffer preparation strategy for single-use bioprocessing of monoclonal antibodies |
| title_full | Economic analysis of buffer preparation strategy for single-use bioprocessing of monoclonal antibodies |
| title_fullStr | Economic analysis of buffer preparation strategy for single-use bioprocessing of monoclonal antibodies |
| title_full_unstemmed | Economic analysis of buffer preparation strategy for single-use bioprocessing of monoclonal antibodies |
| title_short | Economic analysis of buffer preparation strategy for single-use bioprocessing of monoclonal antibodies |
| title_sort | economic analysis of buffer preparation strategy for single use bioprocessing of monoclonal antibodies |
| topic | Concentrated buffer Ready-to-use buffer Downstream processing Monoclonal antibody In-line dilution |
| url | http://www.sciencedirect.com/science/article/pii/S266704102400003X |
| work_keys_str_mv | AT takaoito economicanalysisofbufferpreparationstrategyforsingleusebioprocessingofmonoclonalantibodies AT annkathrinuebele economicanalysisofbufferpreparationstrategyforsingleusebioprocessingofmonoclonalantibodies AT takashinihei economicanalysisofbufferpreparationstrategyforsingleusebioprocessingofmonoclonalantibodies AT koichiyamamoto economicanalysisofbufferpreparationstrategyforsingleusebioprocessingofmonoclonalantibodies AT naotowatanabe economicanalysisofbufferpreparationstrategyforsingleusebioprocessingofmonoclonalantibodies AT yoshiyukitokieda economicanalysisofbufferpreparationstrategyforsingleusebioprocessingofmonoclonalantibodies AT masakiokada economicanalysisofbufferpreparationstrategyforsingleusebioprocessingofmonoclonalantibodies |