Economic analysis of buffer preparation strategy for single-use bioprocessing of monoclonal antibodies

Economic analysis of buffer preparation strategy for single-use bioprocessing of monoclonal antibodies

The total cost of buffer preparation was analyzed for an existing single-use mAbs downstream processing facility. The cost effectiveness of outsourcing the liquid buffer as a ready-to-use and/or concentrate was examined by comparing a traditional made-in-house buffer from solid ingredients. The anal...

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Bibliographic Details
Main Authors: Takao ITO, Ann-Kathrin Uebele, Takashi Nihei, Koichi Yamamoto, Naoto Watanabe, Yoshiyuki Tokieda, Masaki Okada
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:EFB Bioeconomy Journal
Subjects:
Concentrated buffer
Ready-to-use buffer
Downstream processing
Monoclonal antibody
In-line dilution
Online Access:http://www.sciencedirect.com/science/article/pii/S266704102400003X
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