KLF5 loss sensitizes cells to ATR inhibition and is synthetic lethal with ARID1A deficiency

KLF5 loss sensitizes cells to ATR inhibition and is synthetic lethal with ARID1A deficiency

Abstract ATR plays key roles in cellular responses to DNA damage and replication stress, a pervasive feature of cancer cells. ATR inhibitors (ATRi) are in clinical development for treating various cancers, including those with high replication stress, such as is elicited by ARID1A deficiency, but th...

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Main Authors: Samah W. Awwad, Colm Doyle, Josie Coulthard, Aldo S. Bader, Nadia Gueorguieva, Simon Lam, Vipul Gupta, Rimma Belotserkovskaya, Tuan-Anh Tran, Shankar Balasubramanian, Stephen P. Jackson
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55637-5
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https://doi.org/10.1038/s41467-024-55637-5

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