Risk Factors, Clinical Characteristics, and Antibiotic Susceptibility Patterns of <i>Streptococcal</i> Keratitis: An 18-Year Retrospective Study from a Tertiary Hospital in China
<b>Purpose:</b> Our aim was to investigate risk factors, clinical characteristics, and antibiotic susceptibility patterns of cornea-isolated <i>Streptococcus</i> species collected at a tertiary hospital in China over 18 years. <b>Methods:</b> This retrospective st...
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2024-12-01
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| author | Zhen Cheng Qingquan Shi Bo Peng Zijun Zhang Zhenyu Wei Zhiqun Wang Yang Zhang Kexin Chen Xizhan Xu Xinxin Lu Qingfeng Liang |
| author_facet | Zhen Cheng Qingquan Shi Bo Peng Zijun Zhang Zhenyu Wei Zhiqun Wang Yang Zhang Kexin Chen Xizhan Xu Xinxin Lu Qingfeng Liang |
| author_sort | Zhen Cheng |
| collection | DOAJ |
| description | <b>Purpose:</b> Our aim was to investigate risk factors, clinical characteristics, and antibiotic susceptibility patterns of cornea-isolated <i>Streptococcus</i> species collected at a tertiary hospital in China over 18 years. <b>Methods:</b> This retrospective study reviewed data from 350 patients diagnosed with <i>Streptococcal</i> keratitis at Beijing Tongren Hospital between January 2006 and December 2023, including demographics, risk factors, clinical signs, in vivo confocal microscopy (IVCM) imaging, and antibiotic susceptibility testing. <b>Results:</b> The predominant type was <i>Streptococcus pneumoniae</i> (n = 108, 29.8%), followed by <i>Streptococcus mitis</i> (n = 90, 24.9%) and <i>Streptococcus oralis</i> (n = 85, 23.5%). Main risk factors included previous ocular surface disease (24.6%), ocular surgery (21.4%), and trauma (16.3%). Significant differences in clinical characteristics were observed among <i>S. pneumoniae</i>, <i>S. oralis</i>, and <i>S. mitis</i> regarding infiltration location (<i>p</i> = 0.038) and size (<i>p</i> = 0.037), as well as hypopyon presence (<i>p</i> = 0.006). IVCM revealed deeper inflammatory cell distribution and structural disruption as the disease progressed. Resistance rates of aminoglycosides, β-lactams, and fluoroquinolones have increased, with significant differences among species for amikacin (<i>p</i> = 0.010), gentamicin (<i>p</i> = 0.007), and others. Poor outcomes correlated with disease duration over one month, central corneal ulcers, dense infiltrations, hypopyon, and scar tissue presence on IVCM. <b>Conclusions:</b><i>Streptococcal</i> keratitis is a complex ocular infection with multiple risk factors. <i>S. pneumoniae</i>, <i>S. mitis</i>, and <i>S. oralis</i> are the primary causative agents, exhibiting varying clinical features and antibiotic resistance patterns. Key factors associated with poor outcomes include long disease duration, central corneal ulcers, and severe infiltration. |
| format | Article |
| id | doaj-art-fda609a758434b70bc3bebc204930672 |
| institution | Kabale University |
| issn | 2079-6382 |
| language | English |
| publishDate | 2024-12-01 |
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| series | Antibiotics |
| spelling | doaj-art-fda609a758434b70bc3bebc2049306722024-12-27T14:06:19ZengMDPI AGAntibiotics2079-63822024-12-011312119010.3390/antibiotics13121190Risk Factors, Clinical Characteristics, and Antibiotic Susceptibility Patterns of <i>Streptococcal</i> Keratitis: An 18-Year Retrospective Study from a Tertiary Hospital in ChinaZhen Cheng0Qingquan Shi1Bo Peng2Zijun Zhang3Zhenyu Wei4Zhiqun Wang5Yang Zhang6Kexin Chen7Xizhan Xu8Xinxin Lu9Qingfeng Liang10Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, ChinaBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, ChinaBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, ChinaBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, ChinaBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, ChinaBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, ChinaBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, ChinaBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, ChinaBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, ChinaBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, ChinaBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China<b>Purpose:</b> Our aim was to investigate risk factors, clinical characteristics, and antibiotic susceptibility patterns of cornea-isolated <i>Streptococcus</i> species collected at a tertiary hospital in China over 18 years. <b>Methods:</b> This retrospective study reviewed data from 350 patients diagnosed with <i>Streptococcal</i> keratitis at Beijing Tongren Hospital between January 2006 and December 2023, including demographics, risk factors, clinical signs, in vivo confocal microscopy (IVCM) imaging, and antibiotic susceptibility testing. <b>Results:</b> The predominant type was <i>Streptococcus pneumoniae</i> (n = 108, 29.8%), followed by <i>Streptococcus mitis</i> (n = 90, 24.9%) and <i>Streptococcus oralis</i> (n = 85, 23.5%). Main risk factors included previous ocular surface disease (24.6%), ocular surgery (21.4%), and trauma (16.3%). Significant differences in clinical characteristics were observed among <i>S. pneumoniae</i>, <i>S. oralis</i>, and <i>S. mitis</i> regarding infiltration location (<i>p</i> = 0.038) and size (<i>p</i> = 0.037), as well as hypopyon presence (<i>p</i> = 0.006). IVCM revealed deeper inflammatory cell distribution and structural disruption as the disease progressed. Resistance rates of aminoglycosides, β-lactams, and fluoroquinolones have increased, with significant differences among species for amikacin (<i>p</i> = 0.010), gentamicin (<i>p</i> = 0.007), and others. Poor outcomes correlated with disease duration over one month, central corneal ulcers, dense infiltrations, hypopyon, and scar tissue presence on IVCM. <b>Conclusions:</b><i>Streptococcal</i> keratitis is a complex ocular infection with multiple risk factors. <i>S. pneumoniae</i>, <i>S. mitis</i>, and <i>S. oralis</i> are the primary causative agents, exhibiting varying clinical features and antibiotic resistance patterns. Key factors associated with poor outcomes include long disease duration, central corneal ulcers, and severe infiltration.https://www.mdpi.com/2079-6382/13/12/1190<i>Streptococcal</i> keratitisbacterial keratitiseye infectionantibiotic resistance |
| spellingShingle | Zhen Cheng Qingquan Shi Bo Peng Zijun Zhang Zhenyu Wei Zhiqun Wang Yang Zhang Kexin Chen Xizhan Xu Xinxin Lu Qingfeng Liang Risk Factors, Clinical Characteristics, and Antibiotic Susceptibility Patterns of <i>Streptococcal</i> Keratitis: An 18-Year Retrospective Study from a Tertiary Hospital in China Antibiotics <i>Streptococcal</i> keratitis bacterial keratitis eye infection antibiotic resistance |
| title | Risk Factors, Clinical Characteristics, and Antibiotic Susceptibility Patterns of <i>Streptococcal</i> Keratitis: An 18-Year Retrospective Study from a Tertiary Hospital in China |
| title_full | Risk Factors, Clinical Characteristics, and Antibiotic Susceptibility Patterns of <i>Streptococcal</i> Keratitis: An 18-Year Retrospective Study from a Tertiary Hospital in China |
| title_fullStr | Risk Factors, Clinical Characteristics, and Antibiotic Susceptibility Patterns of <i>Streptococcal</i> Keratitis: An 18-Year Retrospective Study from a Tertiary Hospital in China |
| title_full_unstemmed | Risk Factors, Clinical Characteristics, and Antibiotic Susceptibility Patterns of <i>Streptococcal</i> Keratitis: An 18-Year Retrospective Study from a Tertiary Hospital in China |
| title_short | Risk Factors, Clinical Characteristics, and Antibiotic Susceptibility Patterns of <i>Streptococcal</i> Keratitis: An 18-Year Retrospective Study from a Tertiary Hospital in China |
| title_sort | risk factors clinical characteristics and antibiotic susceptibility patterns of i streptococcal i keratitis an 18 year retrospective study from a tertiary hospital in china |
| topic | <i>Streptococcal</i> keratitis bacterial keratitis eye infection antibiotic resistance |
| url | https://www.mdpi.com/2079-6382/13/12/1190 |
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