A compilation of 13 patients with metastatic colorectal cancer and concomitant BRAF and RAS family mutations

A compilation of 13 patients with metastatic colorectal cancer and concomitant BRAF and RAS family mutations

IntroductionMetastatic colorectal cancer (mCRC) exhibits significant heterogeneity in molecular profiles, influencing treatment response and patient outcomes. Mutations in v-raf murine sarcoma viral oncogene homolog B1 (BRAF) and rat sarcoma (RAS) family genes are commonly observed in mCRC. Though o...

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Bibliographic Details
Main Authors: Jigisha Srivastav, Morgan E. Lehman, Joni K. Evans, Ravi Paluri, Caio Max Sao Pedro Rocha Lima
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
BRAF mutation
KRAS mutation
NRAS mutation
RAS family mutation
concurrent RAS/BRAF variants
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1621412/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1621412/full

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