Large-scale predictions of alternative protein conformations by AlphaFold2-based sequence association
Abstract The many successes of AlphaFold2 (AF2) have inspired methods to predict multiple protein conformations, many of which have biological significance. These methods often assume that AF2 relies on evolutionary couplings to predict alternative protein conformations, but they perform poorly on f...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-60759-5 |
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