Comprehensive network pharmacology and experimentation to unveil the therapeutic efficacy and mechanisms of gypenoside LI in anaplastic thyroid cancer

Comprehensive network pharmacology and experimentation to unveil the therapeutic efficacy and mechanisms of gypenoside LI in anaplastic thyroid cancer

Abstract Background Anaplastic thyroid cancer (ATC) is a markedly invasive subtype of thyroid cancer with a poor prognosis. The Gynostemma pentaphyllum-derived Gypenoside LI (Gyp LI) can inhibit the growth and metastasis of various tumors. This study was designed to evaluate the pharmacological mech...

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Main Authors: Meiyu Liu, Haidong Liao, Qin Peng, Junwei Huang, Weixiang Liu, Mengqiao Dai, Zanbing Li, Yang Xie, Jiafeng Liu, Yong Ying, Xiangtai Zeng
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Cancer
Subjects:
Gypenoside LI
Anaplastic thyroid cancer
Network pharmacology
SRC/ PI3K/AKT signaling pathway
Iodine uptake
Online Access:https://doi.org/10.1186/s12885-025-14231-8
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https://doi.org/10.1186/s12885-025-14231-8

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