Collagen crosslinking-induced corneal morphological changes: a three-dimensional light sheet Microscopy-based evaluation

Collagen crosslinking-induced corneal morphological changes: a three-dimensional light sheet Microscopy-based evaluation

Abstract Stiffness-related eye diseases such as keratoconus require comprehensive visualization of the complex morphological matrix changes. The aim of this study was to use three-dimensional (3D) light sheet fluorescence microscopy (LSFM) to analyze unlabeled corneal tissue samples, qualitatively v...

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Bibliographic Details
Main Authors: Axel Stoecker, Diana Pinkert-Leetsch, Timea Koch, Roland Ackermann, Stefan Nolte, Christian van Oterendorp, Christoph Russmann, Jeannine Missbach-Guentner
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Extracellular matrix stiffness
Corneal stroma
Light sheet microscopy
Tomographic microscopy
Autofluorescence
3D virtual histology
Online Access:https://doi.org/10.1038/s41598-024-78516-x
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https://doi.org/10.1038/s41598-024-78516-x

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