Genomic and Phenotypic Variations Among Thai-53 and <i>Mycobacterium leprae</i> Clinical Isolates: Implications for Leprosy Pathogenesis and Research

Genomic and Phenotypic Variations Among Thai-53 and <i>Mycobacterium leprae</i> Clinical Isolates: Implications for Leprosy Pathogenesis and Research

Throughout <i>Mycobacterium leprae’s</i> (<i>M. leprae</i>) evolutionary trajectory, nearly half of its genome was converted into pseudogenes. Despite this drastic reduction in genetic content, the genome sequence identity among <i>M. leprae</i> isolates worldwide...

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Main Authors: Tiago Araujo Gomes, Tatiana Pereira da Silva, Edson Machado, Sidra Ezidio Gonçalves Vasconcelos, Bruno Siqueira Mietto, Daniela Ferreira de Faria Bertoluci, Patricia Sammarco Rosa, Roberta Olmo Pinheiro, Philip Noel Suffys, Letícia Miranda Santos Lery, Flavio Alves Lara
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pathogens
Subjects:
leprosy
non-synonymous mutations
single nucleotide polymorphs
SNPs
Thai-53
Br014-03
Online Access:https://www.mdpi.com/2076-0817/13/11/986
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