Yokukansan (Kampo medicinal formula) prevents the development of morphine tolerance by inhibiting the secretion of orexin A

Yokukansan (Kampo medicinal formula) prevents the development of morphine tolerance by inhibiting the secretion of orexin A

Background: Yokukansan (YKS), a traditional herbal (Kampo) medicine consisting of seven herbs, is effective in the treatment of pain disorders, such as headache, postherpetic neuralgia, fibromyalgia, and trigeminal neuralgia, and we have previously shown it to be effective against morphine analgesic...

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Main Authors: Ayami Katayama, Yasuaki Kanada, Mana Tsukada, Yuko Akanuma, Haruka Takemura, Takahiro Ono, Hiroki Suga, Hitoshi Mera, Tadashi Hisamitsu, Masataka Sunagawa
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Integrative Medicine Research
Online Access:http://www.sciencedirect.com/science/article/pii/S2213422017302640
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