Ecological multivariate assisted spectrophotometric methods for determination of antipyrine and benzocaine HCl in presence of antipyrine official impurity and benzocaine HCl degradant: toward greenness and whiteness

Ecological multivariate assisted spectrophotometric methods for determination of antipyrine and benzocaine HCl in presence of antipyrine official impurity and benzocaine HCl degradant: toward greenness and whiteness

Abstract A simple and green chemometrics-assisted spectrophotometric technique has beendeveloped and validated for the determination of antipyrine (ANT) and benzocaine HCl (BEN) along with the official impurity of ANT, antipyrine impurity A (ANT imp-A), and the degradation product of BEN, p-amino be...

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Bibliographic Details
Main Authors: Khadiga M. Kelani, Maha A. Hegazy, Amal M. Hassan, Ahmed H. Nadim
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Chemistry
Subjects:
Antipyrine
Benzocaine HCl
Partial least squares
Artificial neural network
Green analytical chemistry
Multivariate curve resolution-alternating least squares
Online Access:https://doi.org/10.1186/s13065-024-01352-7
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