Multiplex detection of ten ESR1 mutations and AKT1 E17K in breast cancer using digital PCR

Introduction: ESR1 mutations are now established as a key mechanism of resistance to endocrine therapy in estrogen-receptor–positive breast cancer (ER​+ ​breast cancer) and their sensitive and specific detection in plasma-cell free DNA (plasma-cfDNA) is crucial to monitor during patient treatment. I...

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Main Authors: Stavroula Smilkou, Aliki Ntzifa, Dimitra Stergiopoulou, Vasilis Georgoulias, Evi Lianidou
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:The Journal of Liquid Biopsy
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Online Access:http://www.sciencedirect.com/science/article/pii/S2950195424000195
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