Osteoclast-independent osteocyte dendrite defects in mice bearing the osteogenesis imperfecta-causing Sp7 R342C mutation

Osteoclast-independent osteocyte dendrite defects in mice bearing the osteogenesis imperfecta-causing Sp7 R342C mutation

Abstract Osteogenesis imperfecta (OI) is a group of diseases caused by defects in type I collagen processing which result in skeletal fragility. While these disorders have been regarded as defects in osteoblast function, the role of matrix-embedded osteocytes in OI pathogenesis remains largely unkno...

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Main Authors: Jialiang S. Wang, Katelyn Strauss, Caroline Houghton, Numa Islam, Sung-Hee Yoon, Tatsuya Kobayashi, Daniel J. Brooks, Mary L. Bouxsein, Yingshe Zhao, Cristal S. Yee, Tamara N. Alliston, Marc N. Wein
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-025-00440-1
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https://doi.org/10.1038/s41413-025-00440-1

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