Immunogenic and Protective Features of the Recombinant Vaccinia Virus Strain Expressing Cassette of Genes of Marburg Virus Structural Proteins

Immunogenic and Protective Features of the Recombinant Vaccinia Virus Strain Expressing Cassette of Genes of Marburg Virus Structural Proteins

The aim of the study was to create a highly immunogenic vaccine construct based on a recombinant variant of a replication-defective MVA strain of vaccinia virus, expressing virus-like particles that mimic natural infection with Marburg virus. Materials and methods. The recombinant virus was obtained...

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Main Authors: A. V. Semenova, G. F. Sivolobova, A. A. Grazhdantseva, S. A. P’yankov, I. S. Shul’gina, O. S. Taranov, O. V. P’yankov, D. V. Antonets, L. I. Karpenko, E. V. Starostina, M. V. Borgoyakova, A. N. Chikaev, E. V. Gavrilova, R. A. Maksyutov, G. V. Kochneva
Format: Article
Language:Russian
Published: Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” 2022-01-01
Series:Проблемы особо опасных инфекций
Subjects:
mva strain of vaccinia virus
virus-like particles (vlp)
marburg virus (marv)
surface glycoprotein (gp)
virion protein vp40
intracellular cytokine staining (ics)
Online Access:https://journal.microbe.ru/jour/article/view/1604
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