Deciphering the inhibitory effects of trimetazidine on pulmonary hypertension development via decreasing fatty acid oxidation and promoting glucose oxidation

Deciphering the inhibitory effects of trimetazidine on pulmonary hypertension development via decreasing fatty acid oxidation and promoting glucose oxidation

Abstract Pulmonary hypertension (PH) is a devastating disease characterized by vascular remodeling, resulting in right ventricular failure and death. Dysregulation of energy metabolism is linked to PH pathogenesis. Trimetazidine (TMZ), a selective long-chain 3-ketoacyl coenzyme A thiolase inhibitor,...

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Main Authors: Asako Yanagisawa, Jun-Dal Kim, Akira Naito, Takayuki Kobayashi, Tomoko Misawa, Seiichiro Sakao, Takayuki Jujo-Sanada, Takeshi Kawasaki, Shin-ichi Muroi, So-Ichiro Sasaki, Takuji Suzuki, Yoshihiro Hayakawa, Yoshimi Nakagawa, Yoshitoshi Kasuya, Koichiro Tatsumi
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Pulmonary hypertension
Trimetazidine
Pulmonary transcriptome
Cardiac metabolome
SU5416-hypoxia
Online Access:https://doi.org/10.1038/s41598-024-76100-x
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https://doi.org/10.1038/s41598-024-76100-x

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