Immune monitoring of trabectedin therapy in refractory soft tissue sarcoma patients - the IMMUNYON study

Immune monitoring of trabectedin therapy in refractory soft tissue sarcoma patients - the IMMUNYON study

Soft tissue sarcomas (STS) encompass over 50 histologic subtypes, representing more than 1% of solid tumors. Standard treatments include surgical resection and therapies such as anthracyclines or trabectedin for advanced cases, though challenges persist due to the tumor microenvironment’s complexity...

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Bibliographic Details
Main Authors: Paulo Rodrigues-Santos, Jani Sofia Almeida, Luana Madalena Sousa, Patrícia Couceiro, António Martinho, Joana Rodrigues, Ruben Fonseca, Manuel Santos-Rosa, Paulo Freitas-Tavares, José Manuel Casanova
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
soft tissue sarcoma
trabectedin
immunophenotyping
gene expression profiling
soluble factors
immune checkpoints
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1516793/full
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