Gene therapy in the putamen for curing AADC deficiency and Parkinson's disease

Gene therapy in the putamen for curing AADC deficiency and Parkinson's disease

Abstract This commentary provides an overview of the putamen as an established target site for gene therapy in treating aromatic l‐amino acid decarboxylase (AADC) deficiency and Parkinson’s disease, two debilitating neurological disorders that involve motor dysfunction caused by dopamine deficiencie...

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Bibliographic Details
Main Authors: Paul Wuh‐Liang Hwu, Karl Kiening, Irina Anselm, David R Compton, Takeshi Nakajima, Thomas Opladen, Phillip L Pearl, Agathe Roubertie, Thomas Roujeau, Shin‐ichi Muramatsu
Format: Article
Language:English
Published: Springer Nature 2021-08-01
Series:EMBO Molecular Medicine
Subjects:
AADC deficiency
aromatic l‐amino acid decarboxylase
dopamine
gene therapy
putamen
Online Access:https://doi.org/10.15252/emmm.202114712
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https://doi.org/10.15252/emmm.202114712

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