Engineering spatially-confined conduits to tune nerve self-organization and allodynic responses via YAP-mediated mechanotransduction

Engineering spatially-confined conduits to tune nerve self-organization and allodynic responses via YAP-mediated mechanotransduction

Abstract Chronic allodynia stemming from peripheral stump neuromas can persist for extended periods, significantly compromising patients’ quality of life. Conventional managements for nerve stumps have demonstrated limited effectiveness in ensuring their orderly termination. In this study, we presen...

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Main Authors: Xiaobin Luo, Jia Yang, Yonggang Zhao, Toshitatsu Nagayasu, Junlin Chen, Peilun Hu, Zhi He, Zifan Li, Jun Wu, Zhe Zhao, Guman Duan, Xiaodan Sun, Lingyun Zhao, Yongwei Pan, Xiumei Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55118-9
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