Analysis of Powassan Virus Genome Sequences from Human Cases Reveals Substantial Genetic Diversity with Implications for Molecular Assay Development

Analysis of Powassan Virus Genome Sequences from Human Cases Reveals Substantial Genetic Diversity with Implications for Molecular Assay Development

Powassan virus (POWV) is an emerging tick-borne virus that causes severe meningoencephalitis in the United States, Canada, and Russia. Serology is generally the preferred diagnostic modality, but PCR on cerebrospinal fluid, blood, or urine has an important role, particularly in immunocompromised pat...

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Bibliographic Details
Main Authors: Erik H. Klontz, Navid Chowdhury, Nolan Holbrook, Isaac H. Solomon, Sam R. Telford, Matthew T. Aliota, Chantal B. F. Vogels, Nathan D. Grubaugh, Jeffrey Helgager, Holly R. Hughes, Jason Velez, Anne Piantadosi, Charles Y. Chiu, Jacob Lemieux, John A. Branda
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Viruses
Subjects:
Powassan
deer tick virus
lineage I
PCR
Online Access:https://www.mdpi.com/1999-4915/16/11/1653
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