Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques

Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques

Abstract During infection, the fusion peptide (FP) of HIV envelope glycoprotein (Env) serves a central role in viral fusion with the host cell. As such, the FP is highly conserved and therefore an attractive epitope for vaccine design. Here, we describe a vaccination study in non-human primates (NHP...

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Main Authors: Payal P. Pratap, Christopher A. Cottrell, James Quinn, Diane G. Carnathan, Daniel L. V. Bader, Andy S. Tran, Chiamaka A. Enemuo, Julia T. Ngo, Sara T. Richey, Hongmei Gao, Xiaoying Shen, Kelli M. Greene, Jonathan Hurtado, Katarzyna Kaczmarek Michaels, Elana Ben-Akiva, Ashley Lemnios, Mariane B. Melo, Joel D. Allen, Gabriel Ozorowski, Max Crispin, Bryan Briney, David Montefiori, Guido Silvestri, Darrell J. Irvine, Shane Crotty, Andrew B. Ward
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01252-4
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https://doi.org/10.1038/s41541-025-01252-4

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