Phosphorylation of S‐S‐S Motif in Nuclear Export Protein (NEP) Plays a Critical Role in Viral Ribonucleoprotein (vRNP) Nuclear Export of Influenza A and B Viruses

Phosphorylation of S‐S‐S Motif in Nuclear Export Protein (NEP) Plays a Critical Role in Viral Ribonucleoprotein (vRNP) Nuclear Export of Influenza A and B Viruses

Abstract The phosphorylation of three highly conserved serine residues S23, S24, and S25 (S‐S‐S motif) has been previously identified in NEP of influenza virus. However, it remains obscure whether and how this motif regulates the vRNPs nuclear export. Here the influenza A H5N6 viruses harboring NEP...

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Main Authors: Xiaokun Liu, Cha Yang, Xian Lin, Xiaomei Sun, Huanchun Chen, Qiang Zhang, Meilin Jin
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
ATM
CK2
influenza virus
NEP S‐S‐S motif phosphorylation
vRNP nuclear export
Online Access:https://doi.org/10.1002/advs.202309477
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https://doi.org/10.1002/advs.202309477

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