Synthesis, Crystal Structures, Antimicrobial Activity, and Acute Toxicity Evaluation of Chiral Zn(II) Schiff Base Complexes
Four mononuclear bioefficient zinc coordination complexes [Zn(NN)<sub>3</sub>](ClO<sub>4</sub>)<sub>2</sub> (<b>A</b>–<b>D</b>) involving chiral bidentate Schiff base ligands have been synthesized and characterized by IR, <sup>1</s...
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2024-11-01
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| author | Daniela Gutiérrez Arguelles Claudia P. Villamizar Eduardo Brambila-Colombres Bertin Anzaldo Angel Mendoza Guadalupe Hernández Téllez Pankaj Sharma |
| author_facet | Daniela Gutiérrez Arguelles Claudia P. Villamizar Eduardo Brambila-Colombres Bertin Anzaldo Angel Mendoza Guadalupe Hernández Téllez Pankaj Sharma |
| author_sort | Daniela Gutiérrez Arguelles |
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| description | Four mononuclear bioefficient zinc coordination complexes [Zn(NN)<sub>3</sub>](ClO<sub>4</sub>)<sub>2</sub> (<b>A</b>–<b>D</b>) involving chiral bidentate Schiff base ligands have been synthesized and characterized by IR, <sup>1</sup>H, and <sup>13</sup>C NMR spectroscopy and mass spectrometry. X-ray crystal structures of three of the zinc complexes revealed that the zinc metal ion is hexacoordinated, exhibiting a distorted octahedral geometry where both the nitrogen atoms (NN = pyridyl and imine) of imines are coordinated to the central zinc ion. The isolated zinc complexes were evaluated for their antimicrobial activity in vitro against <i>Escherichia coli</i>, <i>Pseudomonas aeruginosa</i>, and <i>Staphylococcus aureus</i>, displaying varying levels of growth inhibition. An acute toxicity test conducted using <i>Artemia salina</i> and Swiss albino mice showed that the zinc complexes <b>A</b>–<b>D</b> were non-toxic towards <i>A. salina</i> at concentrations below 414, 564, 350, and 385 µM, respectively, and did not affect liver biochemical parameters, although pyknosis was induced in hepatocytes of the treated mice. |
| format | Article |
| id | doaj-art-fad81d5a2fc2477aa8da640f63c76d40 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-11-01 |
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| series | Molecules |
| spelling | doaj-art-fad81d5a2fc2477aa8da640f63c76d402024-12-13T16:28:16ZengMDPI AGMolecules1420-30492024-11-012923555510.3390/molecules29235555Synthesis, Crystal Structures, Antimicrobial Activity, and Acute Toxicity Evaluation of Chiral Zn(II) Schiff Base ComplexesDaniela Gutiérrez Arguelles0Claudia P. Villamizar1Eduardo Brambila-Colombres2Bertin Anzaldo3Angel Mendoza4Guadalupe Hernández Téllez5Pankaj Sharma6Laboratory Síntesis de Complejos, Faculty Ciencias Químicas, Universidad Autónoma de Puebla, Edif. FCQ-6, C.U. Av. San Claudio y Blvd. 14 Sur, Col. San Manuel, Puebla C.P. 72592, MexicoInstituto de Química-UNAM, Circuito Exterior, C.U. Coyoacán, Mexico City C.P. 04510, MexicoLaboratory Síntesis de Complejos, Faculty Ciencias Químicas, Universidad Autónoma de Puebla, Edif. FCQ-6, C.U. Av. San Claudio y Blvd. 14 Sur, Col. San Manuel, Puebla C.P. 72592, MexicoLaboratory Síntesis de Complejos, Faculty Ciencias Químicas, Universidad Autónoma de Puebla, Edif. FCQ-6, C.U. Av. San Claudio y Blvd. 14 Sur, Col. San Manuel, Puebla C.P. 72592, MexicoCentro de Química del Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, 18 Sur y Av. San Claudio, Col. San Manuel, Puebla C.P. 72570, MexicoLaboratory Síntesis de Complejos, Faculty Ciencias Químicas, Universidad Autónoma de Puebla, Edif. FCQ-6, C.U. Av. San Claudio y Blvd. 14 Sur, Col. San Manuel, Puebla C.P. 72592, MexicoInstituto de Química-UNAM, Circuito Exterior, C.U. Coyoacán, Mexico City C.P. 04510, MexicoFour mononuclear bioefficient zinc coordination complexes [Zn(NN)<sub>3</sub>](ClO<sub>4</sub>)<sub>2</sub> (<b>A</b>–<b>D</b>) involving chiral bidentate Schiff base ligands have been synthesized and characterized by IR, <sup>1</sup>H, and <sup>13</sup>C NMR spectroscopy and mass spectrometry. X-ray crystal structures of three of the zinc complexes revealed that the zinc metal ion is hexacoordinated, exhibiting a distorted octahedral geometry where both the nitrogen atoms (NN = pyridyl and imine) of imines are coordinated to the central zinc ion. The isolated zinc complexes were evaluated for their antimicrobial activity in vitro against <i>Escherichia coli</i>, <i>Pseudomonas aeruginosa</i>, and <i>Staphylococcus aureus</i>, displaying varying levels of growth inhibition. An acute toxicity test conducted using <i>Artemia salina</i> and Swiss albino mice showed that the zinc complexes <b>A</b>–<b>D</b> were non-toxic towards <i>A. salina</i> at concentrations below 414, 564, 350, and 385 µM, respectively, and did not affect liver biochemical parameters, although pyknosis was induced in hepatocytes of the treated mice.https://www.mdpi.com/1420-3049/29/23/5555chiral imines and zinc complexesIR and NMR spectroscopic techniquesX-ray crystal structuresantimicrobial activityacute toxicity |
| spellingShingle | Daniela Gutiérrez Arguelles Claudia P. Villamizar Eduardo Brambila-Colombres Bertin Anzaldo Angel Mendoza Guadalupe Hernández Téllez Pankaj Sharma Synthesis, Crystal Structures, Antimicrobial Activity, and Acute Toxicity Evaluation of Chiral Zn(II) Schiff Base Complexes Molecules chiral imines and zinc complexes IR and NMR spectroscopic techniques X-ray crystal structures antimicrobial activity acute toxicity |
| title | Synthesis, Crystal Structures, Antimicrobial Activity, and Acute Toxicity Evaluation of Chiral Zn(II) Schiff Base Complexes |
| title_full | Synthesis, Crystal Structures, Antimicrobial Activity, and Acute Toxicity Evaluation of Chiral Zn(II) Schiff Base Complexes |
| title_fullStr | Synthesis, Crystal Structures, Antimicrobial Activity, and Acute Toxicity Evaluation of Chiral Zn(II) Schiff Base Complexes |
| title_full_unstemmed | Synthesis, Crystal Structures, Antimicrobial Activity, and Acute Toxicity Evaluation of Chiral Zn(II) Schiff Base Complexes |
| title_short | Synthesis, Crystal Structures, Antimicrobial Activity, and Acute Toxicity Evaluation of Chiral Zn(II) Schiff Base Complexes |
| title_sort | synthesis crystal structures antimicrobial activity and acute toxicity evaluation of chiral zn ii schiff base complexes |
| topic | chiral imines and zinc complexes IR and NMR spectroscopic techniques X-ray crystal structures antimicrobial activity acute toxicity |
| url | https://www.mdpi.com/1420-3049/29/23/5555 |
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