PPARγ/ETV2 axis regulates endothelial‐to‐mesenchymal transition in pulmonary hypertension

PPARγ/ETV2 axis regulates endothelial‐to‐mesenchymal transition in pulmonary hypertension

Abstract Endothelial‐to‐mesenchymal transition (EndoMT) plays an important role in pulmonary hypertension (PH) but the molecular mechanisms regulating EndoMT remain to be defined. We demonstrate that the axis of the transcription factors PPARγ (Peroxisome Proliferator‐Activated Receptor gamma) and E...

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Main Authors: Dong Hun Lee, Minseong Kim, Sarah S. Chang, Raham Lee, Andrew J. Jang, Juyoung Kim, Jing Ma, Michael J. Passineau, Raymond L. Benza, Harry Karmouty‐Quintana, Wilbur A. Lam, Benjamin T. Kopp, Roy L. Sutliff, C. Michael Hart, Changwon Park, Bum‐Yong Kang
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Pulmonary Circulation
Subjects:
endothelial‐to‐mesenchymal transition
ETV2
hypoxia
PPARγ
pulmonary hypertension
Online Access:https://doi.org/10.1002/pul2.12448
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https://doi.org/10.1002/pul2.12448

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