Intracranial ependymoma: A retrospective analysis of clinical features, treatment modalities, and long‐term outcome
Abstract Objective Ependymomas, rare neuroglial tumors originating from ependymal cells, can occur in the CNS and typically affect the brain's ventricles or spinal cord. Prognosis is influenced by tumor grade, location, resection extent, and preoperative Karnofsky Performance Status Scale (KPSS...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Aging Medicine |
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| Online Access: | https://doi.org/10.1002/agm2.12378 |
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| author | Amr Badary Sarah Zuhair Kurdi Yasser F. Almealawy Sura N. Alrubaye Vivek Sanker Bipin Chaurasia Oday Atallah |
| author_facet | Amr Badary Sarah Zuhair Kurdi Yasser F. Almealawy Sura N. Alrubaye Vivek Sanker Bipin Chaurasia Oday Atallah |
| author_sort | Amr Badary |
| collection | DOAJ |
| description | Abstract Objective Ependymomas, rare neuroglial tumors originating from ependymal cells, can occur in the CNS and typically affect the brain's ventricles or spinal cord. Prognosis is influenced by tumor grade, location, resection extent, and preoperative Karnofsky Performance Status Scale (KPSS) scores. This study evaluates clinical features, treatment outcomes, and factors affecting prognosis in patients with intracranial ependymomas. Methods A retrospective review of 23 patients with intracranial ependymomas, treated from 2018 to 2023, was conducted. Data included demographics, clinical presentations, KPSS scores, imaging findings, and treatment details. Outcomes assessed were postoperative complications, recurrence rates, and functional status. Statistical analysis used SPSS version 26, with significance set at p < 0.05. Results The cohort was predominantly male (87.0%), with a mean age of 27 years. Tumors were mostly in the fourth ventricle (82.6%), with an average diameter of 68.9 mm. Complete resection was achieved in 87.0% of cases. Postoperative radiotherapy was given to 91.0% of grade 2 and all grade 3 tumors. Recurrence occurred in 17.4% of grade 2 ependymomas, but none of grade 3. The seven‐month mortality rate was 4.3%. Higher preoperative KPSS scores correlated with better outcomes. Conclusion Complete tumor resection and postoperative radiotherapy are crucial for improved outcomes in ependymomas. Higher preoperative KPSS scores and tumor location significantly impact prognosis. Tumors in the lateral ventricles are associated with higher recurrence risks. These findings highlight the need for aggressive surgical management and personalized adjuvant therapy to enhance patient outcomes. |
| format | Article |
| id | doaj-art-fa7d833de3ce4ba6a05b571aed0c21c2 |
| institution | Kabale University |
| issn | 2475-0360 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Aging Medicine |
| spelling | doaj-art-fa7d833de3ce4ba6a05b571aed0c21c22025-01-04T08:39:02ZengWileyAging Medicine2475-03602024-12-017667968810.1002/agm2.12378Intracranial ependymoma: A retrospective analysis of clinical features, treatment modalities, and long‐term outcomeAmr Badary0Sarah Zuhair Kurdi1Yasser F. Almealawy2Sura N. Alrubaye3Vivek Sanker4Bipin Chaurasia5Oday Atallah6Department of Neurosurgery SRH Wald‐Klinikum Gera Gera GermanyDepartment of Neurosurgery University of Kufa Kufa IraqFaculty of Medicine University of Kufa Kufa IraqFaculty of Medicine University of Babylon Hilla IraqDepartment of Neurosurgery Trivandrum Medical College Kerala IndiaDepartment of Neurosurgery Neurosurgery Clinic Birgunj NepalDepartment of Neurosurgery Hannover Medical School Hannover GermanyAbstract Objective Ependymomas, rare neuroglial tumors originating from ependymal cells, can occur in the CNS and typically affect the brain's ventricles or spinal cord. Prognosis is influenced by tumor grade, location, resection extent, and preoperative Karnofsky Performance Status Scale (KPSS) scores. This study evaluates clinical features, treatment outcomes, and factors affecting prognosis in patients with intracranial ependymomas. Methods A retrospective review of 23 patients with intracranial ependymomas, treated from 2018 to 2023, was conducted. Data included demographics, clinical presentations, KPSS scores, imaging findings, and treatment details. Outcomes assessed were postoperative complications, recurrence rates, and functional status. Statistical analysis used SPSS version 26, with significance set at p < 0.05. Results The cohort was predominantly male (87.0%), with a mean age of 27 years. Tumors were mostly in the fourth ventricle (82.6%), with an average diameter of 68.9 mm. Complete resection was achieved in 87.0% of cases. Postoperative radiotherapy was given to 91.0% of grade 2 and all grade 3 tumors. Recurrence occurred in 17.4% of grade 2 ependymomas, but none of grade 3. The seven‐month mortality rate was 4.3%. Higher preoperative KPSS scores correlated with better outcomes. Conclusion Complete tumor resection and postoperative radiotherapy are crucial for improved outcomes in ependymomas. Higher preoperative KPSS scores and tumor location significantly impact prognosis. Tumors in the lateral ventricles are associated with higher recurrence risks. These findings highlight the need for aggressive surgical management and personalized adjuvant therapy to enhance patient outcomes.https://doi.org/10.1002/agm2.12378ependymomaintracranialintraventricularrecurrenceWHO grade |
| spellingShingle | Amr Badary Sarah Zuhair Kurdi Yasser F. Almealawy Sura N. Alrubaye Vivek Sanker Bipin Chaurasia Oday Atallah Intracranial ependymoma: A retrospective analysis of clinical features, treatment modalities, and long‐term outcome Aging Medicine ependymoma intracranial intraventricular recurrence WHO grade |
| title | Intracranial ependymoma: A retrospective analysis of clinical features, treatment modalities, and long‐term outcome |
| title_full | Intracranial ependymoma: A retrospective analysis of clinical features, treatment modalities, and long‐term outcome |
| title_fullStr | Intracranial ependymoma: A retrospective analysis of clinical features, treatment modalities, and long‐term outcome |
| title_full_unstemmed | Intracranial ependymoma: A retrospective analysis of clinical features, treatment modalities, and long‐term outcome |
| title_short | Intracranial ependymoma: A retrospective analysis of clinical features, treatment modalities, and long‐term outcome |
| title_sort | intracranial ependymoma a retrospective analysis of clinical features treatment modalities and long term outcome |
| topic | ependymoma intracranial intraventricular recurrence WHO grade |
| url | https://doi.org/10.1002/agm2.12378 |
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