Clinical factors associated with growth and neoantigen reactivity of tumor infiltrating lymphocytes from metastatic epithelial cancers

Clinical factors associated with growth and neoantigen reactivity of tumor infiltrating lymphocytes from metastatic epithelial cancers

Abstract Background Adoptive cell therapy with tumor infiltrating lymphocytes is FDA approved for metastatic melanoma. TIL from patients with melanoma and factors relating to growth and reactivity have been studied; however, this has not been explored in patients with epithelial cancers. Patients an...

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Main Authors: Alexandra M. Gustafson, Aaron J. Dinerman, Kyle J. Hitscherich, Maria R. Parkhurst, Hyunmi Halas, Donald E. White, Chuong D. Hoang, Jonathan M. Hernandez, Mei Li M. Kwong, Nicholas D. Klemen, Steven A. Rosenberg, Stephanie L. Goff, James C. Yang
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Tumor infiltrating lymphocytes
Metastatic solid tumors
Adoptive cell transfer
Online Access:https://doi.org/10.1007/s00262-025-04091-3
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https://doi.org/10.1007/s00262-025-04091-3

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