Low-dose valine attenuates diet-induced metabolic dysfunction-associated steatotic liver disease (MASLD) in mice by enhancing leptin sensitivity and modulating the gut microbiome

Low-dose valine attenuates diet-induced metabolic dysfunction-associated steatotic liver disease (MASLD) in mice by enhancing leptin sensitivity and modulating the gut microbiome

Objectives: Elevated circulating branched-chain amino acids (BCAAs) have been associated with obesity, insulin resistance, and MASLD. Nonetheless, BCAA supplementation has been shown to provide protective outcomes towards the intervention of MASLD. Currently, there is a lack of study towards the con...

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Main Authors: Felicianna, Emily K.K. Lo, Congjia Chen, Marsena J. Ismaiah, Fangfei Zhang, Hoi Kit Matthew Leung, Hani El-Nezami
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Molecular Metabolism
Subjects:
Valine
Metabolic dysfunction-associated steatotic liver disease (MASLD)
Lipid metabolism
Leptin resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S221287782400190X
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