Peri-implant diseases triggered by oral microdysbiosis: pathogenesis and precision intervention strategies
Peri-implant disease is a chronic infection-induced inflammation condition affecting tissues around dental implants, categorized into peri-implant mucositis and peri-implantitis. Oral microbial dysbiosis plays an important role in this disease. Currently, researchers face three challenges in establi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1639095/full |
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| author | Gang Chen Xin Zhao Xin Zhao Bin Yang Hongzheng Gu |
| author_facet | Gang Chen Xin Zhao Xin Zhao Bin Yang Hongzheng Gu |
| author_sort | Gang Chen |
| collection | DOAJ |
| description | Peri-implant disease is a chronic infection-induced inflammation condition affecting tissues around dental implants, categorized into peri-implant mucositis and peri-implantitis. Oral microbial dysbiosis plays an important role in this disease. Currently, researchers face three challenges in establishing the pathogenic link between peri-implant disease and microdysbiosis: (1) elucidating the underlying molecular mechanisms; (2) Clarifying causal links between host and microbiome; and (3) Identifying secondary microbial changes during disease progression. In this review, we systematically classify dysbiosis from a conceptual perspective and outline the immunological associations within each category. We further elaborate on the causes of bacterial dysbiosis and analyze its potential implications for clinical treatment strategies. At the molecular level, understanding the origins, intrinsic and environmental regulatory mechanisms, and downstream effects may be conducive to develop microbiome targeted therapies. This research direction is of great significance for promoting precision medicine in peri-implant disease. |
| format | Article |
| id | doaj-art-fa3e3430d02c412e99ba25a33c0ce2df |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-fa3e3430d02c412e99ba25a33c0ce2df2025-08-20T03:45:12ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-08-011610.3389/fmicb.2025.16390951639095Peri-implant diseases triggered by oral microdysbiosis: pathogenesis and precision intervention strategiesGang Chen0Xin Zhao1Xin Zhao2Bin Yang3Hongzheng Gu4Department of Implant and Restoration, Zhenjiang Stomatological Hospital, Zhenjiang, ChinaDepartment of Implant and Restoration, Zhenjiang Stomatological Hospital, Zhenjiang, ChinaCentral Laboratory of Zhenjiang Stomatological Hospital, Zhenjiang, ChinaDepartment of Implant and Restoration, Zhenjiang Stomatological Hospital, Zhenjiang, ChinaExpert Consultation Center of Zhenjiang Stomatological Hospital, Zhenjiang, ChinaPeri-implant disease is a chronic infection-induced inflammation condition affecting tissues around dental implants, categorized into peri-implant mucositis and peri-implantitis. Oral microbial dysbiosis plays an important role in this disease. Currently, researchers face three challenges in establishing the pathogenic link between peri-implant disease and microdysbiosis: (1) elucidating the underlying molecular mechanisms; (2) Clarifying causal links between host and microbiome; and (3) Identifying secondary microbial changes during disease progression. In this review, we systematically classify dysbiosis from a conceptual perspective and outline the immunological associations within each category. We further elaborate on the causes of bacterial dysbiosis and analyze its potential implications for clinical treatment strategies. At the molecular level, understanding the origins, intrinsic and environmental regulatory mechanisms, and downstream effects may be conducive to develop microbiome targeted therapies. This research direction is of great significance for promoting precision medicine in peri-implant disease.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1639095/fullperi-implant mucositisperi-implantitisdysbiosisoral pathogenic bacteriaintervention and treatment strategies |
| spellingShingle | Gang Chen Xin Zhao Xin Zhao Bin Yang Hongzheng Gu Peri-implant diseases triggered by oral microdysbiosis: pathogenesis and precision intervention strategies Frontiers in Microbiology peri-implant mucositis peri-implantitis dysbiosis oral pathogenic bacteria intervention and treatment strategies |
| title | Peri-implant diseases triggered by oral microdysbiosis: pathogenesis and precision intervention strategies |
| title_full | Peri-implant diseases triggered by oral microdysbiosis: pathogenesis and precision intervention strategies |
| title_fullStr | Peri-implant diseases triggered by oral microdysbiosis: pathogenesis and precision intervention strategies |
| title_full_unstemmed | Peri-implant diseases triggered by oral microdysbiosis: pathogenesis and precision intervention strategies |
| title_short | Peri-implant diseases triggered by oral microdysbiosis: pathogenesis and precision intervention strategies |
| title_sort | peri implant diseases triggered by oral microdysbiosis pathogenesis and precision intervention strategies |
| topic | peri-implant mucositis peri-implantitis dysbiosis oral pathogenic bacteria intervention and treatment strategies |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1639095/full |
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