Unveiling the hidden interactome of CRBN molecular glues

Unveiling the hidden interactome of CRBN molecular glues

Abstract Induced proximity by molecular glues refers to strategies that leverage the recruitment of proteins to facilitate their modification, regulation or degradation. As prospective design of molecular glues remains challenging, unbiased discovery methods are necessary to discover new chemical ta...

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Main Authors: Kheewoong Baek, Rebecca J. Metivier, Shourya S. Roy Burman, Jonathan W. Bushman, Hojong Yoon, Ryan J. Lumpkin, Julia K. Ryan, Dinah M. Abeja, Megha Lakshminarayan, Hong Yue, Samuel Ojeda, Yuan Xiong, Jianwei Che, Alyssa L. Verano, Anna M. Schmoker, Nathanael S. Gray, Katherine A. Donovan, Eric S. Fischer
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62099-w
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https://doi.org/10.1038/s41467-025-62099-w

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