Oral administration of Porphyromonas gingivalis to mice with diet-induced obesity impairs cognitive function associated with microglial activation in the brain

Oral administration of Porphyromonas gingivalis to mice with diet-induced obesity impairs cognitive function associated with microglial activation in the brain

Objective Both periodontal disease and obesity are risk factors for dementia, but their links to 1brain function remain unclear. In this study, we examined the effects of oral infection with a periodontal pathogen on cognitive function in a mouse model of obesity, focusing on the roles of microglia....

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Main Authors: Kana Oue, Yosuke Yamawaki, Kazuhisa Ouhara, Eiji Imado, Tetsuya Tamura, Mitsuru Doi, Yoshitaka Shimizu, Mitsuhiro Yoshida, Noriyoshi Mizuno, Norimitsu Morioka, Takashi Kanematsu, Masahiro Irifune, Yukio Ago
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Oral Microbiology
Subjects:
Periodontal disease
Porphyromonas gingivalis
oral infection
obesity
cognitive dysfunction
inflammation
Online Access:https://www.tandfonline.com/doi/10.1080/20002297.2024.2419155
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https://www.tandfonline.com/doi/10.1080/20002297.2024.2419155

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