Space exploration and risk of Parkinson’s disease: a perspective review
Abstract Systemic mitochondrial dysfunction, dopamine loss, sustained structural changes in the basal ganglia including reduced tyrosine hydroxylase, and altered gait- these effects observed in space-flown animals and astronauts mirrors Parkinson’s disease (PD). Evidence of mitochondrial changes in...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Microgravity |
| Online Access: | https://doi.org/10.1038/s41526-024-00457-6 |
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| _version_ | 1841559256411668480 |
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| author | Nilufar Ali Afshin Beheshti Greg Hampikian |
| author_facet | Nilufar Ali Afshin Beheshti Greg Hampikian |
| author_sort | Nilufar Ali |
| collection | DOAJ |
| description | Abstract Systemic mitochondrial dysfunction, dopamine loss, sustained structural changes in the basal ganglia including reduced tyrosine hydroxylase, and altered gait- these effects observed in space-flown animals and astronauts mirrors Parkinson’s disease (PD). Evidence of mitochondrial changes in space-flown human cells, examined through the lens of PD, suggests that spaceflight-induced PD-like molecular changes are important to monitor during deep space exploration. These changes, may potentially elevate the risk of PD in astronauts. |
| format | Article |
| id | doaj-art-f9de7650e7fb4ddd805ba4361577377a |
| institution | Kabale University |
| issn | 2373-8065 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Microgravity |
| spelling | doaj-art-f9de7650e7fb4ddd805ba4361577377a2025-01-05T12:42:15ZengNature Portfolionpj Microgravity2373-80652025-01-011111710.1038/s41526-024-00457-6Space exploration and risk of Parkinson’s disease: a perspective reviewNilufar Ali0Afshin Beheshti1Greg Hampikian2Department of Biological Science, Boise State UniversityMcGowan Institute for Regenerative Medicine - Center for Space Biomedicine, Department of Surgery, University of PittsburghDepartment of Biological Science, Boise State UniversityAbstract Systemic mitochondrial dysfunction, dopamine loss, sustained structural changes in the basal ganglia including reduced tyrosine hydroxylase, and altered gait- these effects observed in space-flown animals and astronauts mirrors Parkinson’s disease (PD). Evidence of mitochondrial changes in space-flown human cells, examined through the lens of PD, suggests that spaceflight-induced PD-like molecular changes are important to monitor during deep space exploration. These changes, may potentially elevate the risk of PD in astronauts.https://doi.org/10.1038/s41526-024-00457-6 |
| spellingShingle | Nilufar Ali Afshin Beheshti Greg Hampikian Space exploration and risk of Parkinson’s disease: a perspective review npj Microgravity |
| title | Space exploration and risk of Parkinson’s disease: a perspective review |
| title_full | Space exploration and risk of Parkinson’s disease: a perspective review |
| title_fullStr | Space exploration and risk of Parkinson’s disease: a perspective review |
| title_full_unstemmed | Space exploration and risk of Parkinson’s disease: a perspective review |
| title_short | Space exploration and risk of Parkinson’s disease: a perspective review |
| title_sort | space exploration and risk of parkinson s disease a perspective review |
| url | https://doi.org/10.1038/s41526-024-00457-6 |
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